观察小青龙汤联合孟鲁司特钠治疗儿童咳嗽变异性哮喘的临床疗效

Efficacy of the Xiaoqinglong decoction plus menglusitena on cough variant asthma in children

目的:观察分析在儿童咳嗽变异性哮喘的治疗中应用小青龙汤联合孟鲁司特钠进行治疗的临床效果。方法:将2017年1月-2019年1月本院收治符合纳入标准的儿童咳嗽变异性哮喘患儿96例纳入研究,通过区组随机化分组法进行随机分组,中药联合组48例,单一西药组48例,单一西药组使用孟鲁司特钠进行治疗,中药联合组则使用孟鲁司特钠联合小青龙汤进行治疗,对比两组患儿临床治疗效果、控制起效时间、肺功能、不良反应以及复发情况。结果:实施孟鲁司特钠联合小青龙汤进行治疗的中药联合组患儿,其治疗有效率、控制起效时间、治疗后患儿用力肺活量(Forced Vital Capacity,FVC)、第1秒用力呼吸量(Forced Expiratory Volume in 1 second,FEV1)、呼气峰值流速(Peak Expiratory Flow,PEF)、不良反应发生率及复发情况均优于使用孟鲁司特钠的单一西药组患儿,且两组比较有统计学意义(P <0.05)。结论:在儿童咳嗽变异性哮喘的治疗中使用小青龙汤联合孟鲁司特钠进行治疗较单一使用孟鲁司特钠治疗效果更佳,具体可体现为治疗有效率更高、控制起效时间更早、治疗后患儿肺功能改善更好、药后不良反应更少、复发更迟,减少患儿痛苦,在此类患儿的临床治疗中获得理想治疗效果,可大力推广应用。

Objective: To observe and analyze the clinical effect of the Xiaoqinglong decoction( 小青龙汤) with Menglusitena on cough variant asthma in children. Methods: 96 children were divided into two groups. The single Western medicine group took Menglusitena, and the combined group took Menglusitena and the Xiaoqinglong decoction. The clinical effect, control effect time, lung function, adverse reactions, and recurrence were compared. Results: In the combined group, efficiency, control of the initial effect time, the children’s hard lung activity, the first second hard breathing volume, the peak flow rate of exhalation, adverse reactions and the recurrence are better than the single Western drug group(P<0.05). Conclusion: The Xiaoqinglong decoction with Menglusitena on cough variant asthma in children is more effective, with the earlier control time, the better lung function, the fewer adverse reactions, less pain.