米索前列醇联合缩宫素治疗产后出血的效果分析

The effect of misoprostol plus oxytocin on postpartum hemorrhage

目的:探讨联合应用米索前列醇和缩宫素对产后出血的治疗效果。方法:对我院2012年10月-2017年10月间收治的84例产后出血患者进行研究,根据用药方式分成例数均等的对照组和观察组。对照组用缩宫素治疗,观察组在对照组基础上加用米索前列醇,进行两组疾病治疗效果的对比。结果:对照组和观察组患者治疗前的出血量、红细胞比容和血红蛋白水平间差异无统计学意义(P> 0.05),观察组治疗2 h后出血量为(178.6±18.4)mL,治疗24 h后出血量为(63.8±9.2)mL,红细胞比容为(29.8±3.5)%,血红蛋白水平为(102.1±2.7)g/L,观察组治疗2 h后出血量、治疗24 h后出血量、红细胞比容和血红蛋白水平分别为(272.4±26.2)mL、(110.4±16.9)mL、(25.6±2.1)%和(97.8±1.2)g/L,所得数据间差异有显著性统计学意义(P <0.05);观察组出现不良反应的概率为4.8%(2/24),与对照组不良反应发生率相比,研究数据间差异有明显的统计学意义(P <0.05)。结论:米索前列醇联合缩宫素治疗产后出血,效果明显,安全性高,值得深入探讨,推广应用。

Objective: To explore the effect of misoprostol and oxytocin on postpartum hemorrhage. Methods: A total of 84 patients with postpartum hemorrhage treated in our hospital from October 2012 to October 2017 were studied and divided into the control group and observation group with equal numbers of cases according to the way of medication. The control group was treated with oxytocin, and the observation group was given misoprostol more. Results: The bleeding volume after 2 hours was(63.8±9.2) mL, the hematocrit was(29.8±3.5)%, and the hemoglobin level was(102.1±2.7) g/L in the observation group. And those in the control group were(272.4±26.2) mL,(110.4±16.9) mL,(25.6±2.1)%, and(97.8±1.2) g/L. And there were significant statistical differences in the obtained data between groups(P<0.05). The adverse reactions in the observation group was 4.8%(2/42), lower than the control group(P<0.05). Conclusion: Misoprostol with oxytocin on postpartum hemorrhage has obvious effects and high safety, is worthy of further discussion and promotion.