加味星蒌承气汤对急性缺血性脑卒中患者神经功能及血脂、血液流变学的影响

Effect of Jiawei Xinglou Chengqi Decoction on Nerve Function, Blood Lipid and Hemorheology in Patients with Acute Ischemic Stroke

目的:探讨加味星蒌承气汤对急性缺血性脑卒中患者神经功能及血脂、血液流变学的影响。方法:选取2017年8月~2019年6月期间我院收治的急性缺血性脑卒中患者96例,将入选患者根据随机数字表法分为对照组(n=48)和研究组(n=48),对照组患者予以常规西医治疗,研究组患者在对照组基础上联合加味星蒌承气汤治疗,对比两组患者疗效、神经功能及血脂、血液流变学情况,记录两组患者治疗期间不良反应情况。结果:研究组治疗8 d后的临床总有效率为91.67%(44/48),显著高于对照组患者的72.92%(35/48)(P<0.05)。两组治疗8 d后加拿大神经功能评分量表(CNS)、美国国立卫生研究所卒中量表(NIHSS)评分均下降(P<0.05),且研究组低于对照组(P<0.05)。两组治疗8 d后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、全血黏度高切、全血黏度低切、血浆黏度、纤维蛋白原均下降(P<0.05),且研究组低于对照组(P<0.05);高密度脂蛋白胆固醇(HDL-C)升高(P<0.05),且研究组高于对照组(P<0.05)。两组不良反应发生率比较无明显差异(P>0.05)。结论:急性缺血性脑卒中患者采用加味星蒌承气汤治疗,疗效显著,可有效改善患者神经功能及血脂、血液流变学,且安全性较好。

Objective: To explore the effect of Jiawei Xinglou Chengqi decoction on nerve function, blood lipid and hemorheology in patients with acute ischemic stroke. Methods: 96 patients with acute ischemic stroke who were admitted to our hospital from August 2017 to June 2019 were selected, they were randomly divided into control group(n=48) and study group(n=48) according to the digital table method. The patients in the control group were treated with conventional western medicine. The patients in the study group were treated with Jiawei Xinglou Chengqi decoction on the basis of the control group, and the curative effect, neurological function, blood lipid and hemorheology of the two groups were compared. The adverse reactions during the treatment of the two groups were recorded. Results: The total clinical effective rate of the study group was 91.67%(44/48), which was significantly higher than 72.92%(35/48) of the control group(P<0.05). The scores of Canadian neurological function score scale(CNS) and National Institutes of Health StrokeScale(NIHSS) in the two groups at 8 days after treatment decreased(P<0.05), and the scores in the study group were lower than those in the control group(P<0.05). The total cholesterol(TC), low density lipoprotein(LDL-C), triglyceride(TG), whole blood viscosity high cut, whole blood viscosity low cut, plasma viscosity and fibrinogen in the two groups at 8 days after treatment decreased(P<0.05), and those in the study group were lower than those in the control group(P<0.05), the high density lipoprotein(HDL-C)increased(P<0.05), and that in the study group was higher than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: The therapeutic effect of Jiawei Xinglou Chengqi decoction on the patients with acute ischemic stroke is significant, which can effectively improve the neurologic function, blood lipid and hemorheology of the patients, and it has a good safety.