慢性氯化汞中毒大鼠的心电图变化

Electrocardiogram changes in rats with chronic mercuric poisoning

目的研究慢性氯化汞中毒对大鼠心电图的影响。方法将40只SD大鼠随机分为对照组(生理盐水),低、中、高剂量(335、670、1340μg/kg)氯化汞染毒组,皮下分别注射生理盐水、氯化汞,1次/d,共90 d。染毒结束后,用氨基甲酸乙酯麻醉大鼠,检测血清心肌酶谱,描记Ⅱ导联心电图,测量R波振幅值,J点电压值,T波振幅值,T波头峰斜率及峰尾斜率,计算T/R比值及T波头峰/峰尾斜率比值。结果氯化汞染毒组心肌酶谱高于对照组(P<005)。J点电压及T波振幅染毒组均高于对照组,中、高剂量染毒组高于低剂量组(P<005);T波峰尾段斜率及T波/R波振幅比值随染毒剂量增大而升高(P<005)。结论慢性氯化汞中毒可引起大鼠心肌损伤,心电图改变,并与染毒剂量相关。

Objective To study the chronic toxic effect of mercuric chloride on electrocardiogram in ratsMethods The 40 SD rats were randomly devided into 4 groups:low,medium,high dose of HgCl2 groups(subcutaneous injection once a day/kg HgCl2 for 90 days,respectively)and control group(only injected with NS).90 day later after experiment,the rats were anesthetized with ethyl carbamate,the blood samples were taken for detecting the serum myocardial enzymes,and ECG examination was made as well for the measurement of R wave amplitude value,J point voltage value,and/R ratio and ratio of T wave head to peak-tail slopeResults The results showed that the level of myocardial enzymes,J point voltage value and T wave amplitude in Hg treated groups were all higer than that of control group(P<005),these indeces in medium and high dose groups were even higher than that of low dose group(P<005).Additionally,T wave peak-end slope and T/R wave amplitude ratio were increased with the treated doses of Hg(P<005).Conclusion Chronic exposure to mercuric chloride might lead to some myocardial injury and ECG changes in ECG rats,which is also related to exposure dose.