原发性干燥综合征中高迁移率族蛋白1与免疫失衡的研究进展

Progress in association between high mobility group protein box 1(HMGB1)and immune imbalance in primary Sjögren′s syndrome

原发性干燥综合征(primary Sjogren′s syndrome,pSS)是一种相对常见的自身免疫性的系统性疾病。迄今为止,pSS的发病机制还未完全阐明。随着研究的不断深入,人们发现高迁移率族蛋白1(high mobility group protein box 1,HMGB1)与pSS的发病有关联,且免疫调节异常已成为研究的热点。本文对pSS发病机制中HMGB1与免疫失衡的相关研究进行综述。

Primary Sjögren′s syndrome(pSS)is a relatively common autoimmune systemic disease.The pathogenesis of pSS has not been fully elucidated.With the deepening of research,it is found that high mobility group protein box 1(HMGB1)is associated with the pathogenesis of pSS,and immunomodulatory abnormalities have become a research hotspot.This article reviewed the association between HMGB1 and immune imbalance in the pathogenesis of pSS.