肿瘤化疗患者焦虑抑郁状态的相关影响因素研究

Study on anxiety,depression and related factors of cancer patients with chemotherapy

目的观察肿瘤化疗患者的焦虑抑郁情况,并分析其影响因素。方法选取2016年2月至2017年3月在杭州市富阳区第一人民医院接受化疗的肿瘤患者为研究对象,同时选取同期体检的健康成年人作为对照。观察两组研究对象焦虑、抑郁得分,比较不同临床特征肿瘤化疗患者焦虑、抑郁得分的差异,分析影响肿瘤化疗患者焦虑、抑郁得分的因素。结果肿瘤化疗组的焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)得分分别为(52.75±6.02)分、(54.11±5.76)分,均高于对照组的(28.63±3.48)分、(30.15±4.05)分(t=-42.484、-41.675,P均<0.01);婚姻状况其他、居住地为农村、学历大专及以上、付费方式为自费、知晓病情、化疗时间≥6个月的肿瘤化疗患者SAS、SDS得分较高(P均<0.05);多重逐步回归分析结果显示,付费方式和化疗时间进入回归方程。结论肿瘤化疗患者的焦虑抑郁得分较高,且受付费方式和化疗时间的影响。

Objective To observe the anxiety and depression of cancer patients with chemotherapy,and to analyze the influencing factors.Methods 150tumor patients who received chemotherapy in our hospital from February 2016to March 2017were enrolled in the study.Meanwhile,150matched healthy adults who received physical examination in our hospital during the same period were also selected as study controls.Anxiety selfrating scale(SAS)and depression self-rating scale(SDS)were used to assess the anxiety and depression.Student t test and logistic regression were used for data statistical analysis.Results The scores of SAS and SDS of cancer patients with chemotherapy were significantly higher than that of controls(52.75±6.02 vs 28.63±3.48;54.11±5.76 vs 30.15±4.05;t=-42.484,-41.675,P<0.01).Patients who were from rural areas,well-educated,treated at their own expenses,clear about their illnesses and with more than 6 months of chemotherapy had higher scores of SAS and SDS(P<0.05).Multiple stepwise regression analysis showed that payment method and duration of chemotherapy were associated with anxiety and depression of cancer patients.Conclusions Scores of anxiety and depression of cancer patients undergoing chemotherapy are higher,which are greatly influenced by the payment method and the duration of chemotherapy.