期刊文献+

桥粒在肺部疾病中的研究进展

Progress of desmosomes in pulmonary diseases
原文传递
导出
摘要 桥粒是一种牢固的细胞间连接,通过中间丝锚定于相邻的细胞膜,对维持组织结构完整性具有重要作用。近年来研究表明,桥粒功能异常与肺癌、肺纤维化、硅沉着病以及支气管哮喘等肺部疾病密切相关。本文就上述研究进行综述,探讨桥粒在肺部疾病中的可能作用,有助于进一步了解相关肺部疾病的机制,并为其诊治和预后评估提供新思路。 Desmosomes are adhesive intercellular junctions that anchor intermediate filaments to the plasma membrane.Desmosomes play an important role in the maintenance of tissue integrity.Recent studies have shown that the defects of desmosomes are associated with pulmonary diseases,such as lung cancer,pulmonary fibrosis,silicosis and asthma.This article make a brief review on the research progress of desmosomes in pulmonary diseases to explore the roles and potential mechanisms of desmosomes in pulmonary diseases.It provides new insights into the pathogenesis,diagnosis,treatment and prognosis of related pulmonary diseases.
作者 姚蕾 王燕 姚欣 Yao Lei;Wang Yan;Yao Xin(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处 《国际呼吸杂志》 2020年第10期767-772,共6页 International Journal of Respiration
基金 国家自然科学基金(81870039) 江苏省医学重点人才项目(ZDRCA2016020)。
关键词 桥粒 肺疾病 细胞间连接 Desmosomes Lung diseases Intercellular junction
  • 引文网络
  • 相关文献
;
使用帮助 返回顶部