肺炎链球菌鼻咽部定植及胞内感染的致病机制研究进展

Research progress in pathogenesis of Streptococcus pneumoniae:from nasopharyngeal colonizer to intracellular pathogen

肺炎链球菌是人上呼吸道常见定植菌,但在免疫力低下人群中可引起致死性疾病,如肺炎、菌血症、脑膜炎等。过去,肺炎链球菌常常被认为是一个胞外感染菌,但近年来研究显示其也可以在各种毒力因子相互作用下逃避宿主的免疫反应,在细胞内存活。本文综述了肺炎链球菌从鼻咽部定植发展为在不同器官组织内发生胞内感染的致病机制研究进展。

Streptococcus pneumoniae (the pneumococcus) is a common human colonizer of human upper respiratory tract which can cause lethal diseases such as pneumonia,sepsis and meningitis in immunocompromised patients. Previously considered to be an extracellular pathogen,it is becoming evident that pneumococci may also escape host immune responses and survive in intracellular niches under the interaction of various virulence factors.In this paper,the research advances in the pathogenesis of the Streptococcus pneumoniae: from a nasopharyngeal colonizer to an intracellular pathogen.