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转录因子KLF14在动脉粥样硬化与2型糖尿病和肿瘤进展中的作用

Role of transcription factor KLF14 in atherosclerosis,type 2 diabetes,and tumor progression
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摘要 KLF14作为转录因子中的一员,能与靶基因序列进行特异性的结合,调控靶基因的转录,参与人体生理和病理过程。目前研究发现KLF14在脂肪组织中发挥重要的作用,参与动脉粥样硬化和2型糖尿病疾病的进展,除此之外,作为肿瘤抑制因子参与肿瘤的发生发展。 As one of the transcription factors,KLF14 can specifically bind to target gene sequences,regulate the transcription of target genes,and participate in human physiological and pathological processes.At present,KLF14 plays an important role in adipose tissue,and participates in the progression of atherosclerosis and type 2 diabetes diseases.In addition,it participates in tumor development as a tumor suppressor.
作者 侯玉丽(综述) 王培昌(审校) HOU Yuli;Wang Peichang(Department of Clinical Laboratory,Xuanwu Hospital of Capital Medical University,Beijing 10053,China)
机构地区 首都医科大学宣武医院检验科
出处 《国际检验医学杂志》 CAS 2020年第11期1395-1398,共4页 International Journal of Laboratory Medicine
基金 国家自然科学基金项目(81871714,81472007) 北京市医管局人才培养计划“登峰”基金项目(DFL20180803)。
关键词 KLF14 动脉粥样硬化 2型糖尿病 肿瘤 KLF14 atherosclerosis type 2 diabetes mellitus tumor
分类号 R543.5 [医药卫生—心血管疾病]
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国际检验医学杂志
2020年 第11期

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