细胞焦亡在肝纤维化发生发展中的作用

Role of pyroptosis in the pathogenesis of hepatic fibrosis

肝纤维化是肝脏对各种慢性肝损伤进行自我修复的一种可逆性病理反应,可发展为肝硬化、肝癌。细胞焦亡是有别于细胞凋亡、坏死的细胞新型程序性死亡方式,与肝纤维化发病密切相关。简述了细胞焦亡的概念、激活途径以及在肝星状细胞、肝实质细胞、Kupffer细胞、嗜酸性粒细胞中作用的最新研究进展,指出细胞焦亡可诱发肝脏炎症,过度活化肝星状细胞,促进肝纤维化发生、发展,为其临床诊疗提供了新的思路与潜在靶点。

Hepatic fibrosis is a reversible pathological reaction of the liver during the self-repair of various chronic liver injuries and can progress to liver cirrhosis and liver cancer.Pyroptosis is a new type of programmed cell death different from apoptosis and necrosis and is closely associated with the pathogenesis of hepatic fibrosis.This article reviews the latest research advances in the definition of pyroptosis,related activation pathways,and its role in hepatic stellate cells,hepatic parenchymal cells,Kupffer cells,and eosinophils,and it is pointed out that pyroptosis can induce liver inflammation,excessively activate hepatic stellate cells,and promote the development and progression of hepatic fibrosis,in order to provide new ideas and potential targets for clinical diagnosis and treatment.