Hippo通路在原发性肝癌发生发展中的作用

Role of the Hippo signaling pathway in the development and progression of primary liver cancer

原发性肝癌在全球范围内发病率持续上升,发病年龄趋于年轻化,并且总体预后不良。Hippo通路作为最经典的感知细胞极性和密度、机械信号转导并促进细胞增殖、器官发育的调节器,能够促进包括原发性肝癌在内多种癌症的发生发展。YAP作为Hippo通路的经典核效应器在原发性肝癌中显著上调,并且促进原发性肝癌耐药的发生。原发性肝癌中Hippo信号通路的失调与肝癌的发生发展相联系,Hippo信号通路作为原发性肝癌发生的早期事件,影响原发性肝癌耐药的发生机制,这对于探索新的原发性肝癌临床治疗策略具有重要意义。

The incidence rate of primary liver cancer continues to increase around the world,with a younger age of onset and poorer prognosis.As the most classic regulator of cell polarity and density,mechanical signal transduction,cell proliferation,and organ development,the Hippo pathway can promote the development and progression of various cancers including primary liver cancer.YAP,a classic nuclear effector of the Hippo pathway,is significantly upregulated in primary liver cancer and promotes the development of drug resistance.This article aims to investigate the association of the dysregulation of the Hippo signaling pathway with the development and progression of primary liver cancer and analyzes the mechanism of action of the Hippo signaling pathway in the drug resistance of primary liver cancer as an early event of the development of primary liver cancer,which is of great significance for exploring new treatment strategies for primary liver cancer.