摘要
Patients with Alzheimer’s disease(AD)have progressive memory loss,inability to reason,and display anxiety that accelerates disease progressionJ.Evidence points to two deficits:1)the brain fails to respond to insulin that regulates the formation of neuron connections required to store memories,and 2)deficits arise in the brain’s endogenous cannabinoid signaling that regulates mood and prevents anxiety(Aso and Ferrer,2014).In addition,leptin signaling,important in regulating hypothalamic synaptic plasticity and cognitive function is also affected in AD(McGregor and Harvey,2018).
基金
supported by grants from the Heart and Stroke Foundation of Canada(to HHC,G-13-0002596&G-18-0022157
to AFRS,G-16-00014085)
the Natural Science and Engineering Research Council of Canada(to HHC,RGPIN/06212-2014
to AFRS,RGPIN/2016-04985)
the Canadian Institutes of Health Research(HHC,201610PJT)
supported by a Mid-Career Investigator Award(grant No.7506)from the Heart and Stroke Foundation of Ontario。
