丹蛭降糖胶囊联合缬沙坦治疗气阴两虚型早期糖尿病肾病临床观察

Clinical Observation on Danzhi Jiangtang Capsule Combined with Valsartan in the Treatment of Early Diabetic Nephropathy(Syndrome of Deficiency of both Qi and Yin)

目的观察丹蛭降糖胶囊联合缬沙坦治疗气阴两虚型早期糖尿病肾病的疗效。方法选取了2018年6月-2019午5月安徽省中医院内分泌科80例确诊的气阴两虚型早期糖尿病肾病患者,随机分为观察组和对照组,各40例。所有病人均按标准进行常规血糖控制、饮食和血压控制等生活习惯方面的指导。对照组采用单一的缬沙坦(80 mg/d)治疗,观察组则施用丹蛭降糖胶囊(5.25 g/d)和缬沙坦联合治疗,治疗周期为12周。比较2组患者的空腹血糖(FPG)、餐后2h血糖(2hPG)、尿白蛋白排泄率(UAER)、尿N-乙酰-β-D-葡萄糖苷酶(NAG)、尿微量白蛋白(mALB)、血尿素氮(BUN)以及血清肌酐(SCr)等指标和中医证候积分及并发症情况。结果在治疗周期结束后,观察组FPG、2hPG、UAER、NAG、mALB、BUN、SCr等指标和中医证候积分都低于对照组;且与对照组比较,观察组的FPG、2hPG、UAER、NAG、mALB、BUN、SCr等指标和中医证候积分差异有统计学意义(P<0.05)。结论丹蛭降糖胶囊联合缬沙坦治疗气阴两虚型早期糖尿病肾病,在病理指标和临床症状改善方面具有一定的提升,治疗效果确切,安全性较好。

Objective This work was conducted to observe the curative effect of Danzhi Jiangtang Capsule combined with Valsartan on early diabetic nephropathy.Methods 80 patients with early diabetic nephropathy in the Department of Endocrinology,Anhui Provincial Hospital of Traditional Chinese Medicine from June,2018 to May,2019 were chosen,randomly divided into study group and control group,40 cases each.On the basis of the treatment of Valsartan(control group),the study group was additionally treated with Danzhi Jiangtang Capsule(treatment group).Results The efficacy and total effective rate of TCM syndromes in the study group were better than those in the control group.The blood glucose levels of FPG、2hPG、UAER、NAG、mALB、BUN、and SCr in the study group were more obvious than those in the control group.The urine protein index also showed a certain decrease.Conclusion Danzhi Jiangtang Capsule can improve the efficacy in the treatment of early diabetic nephropathy.