中性粒细胞明胶酶相关脂质运载蛋白在冠心病中的研究进展

Research Progress of Neutrophil Gelatinase-associated Lipocalin in Coronary Heart Disease

近年来心脏标志物领域有了飞速的发展,推动了整体心血管疾病诊断水平的提高。研究表明,中性粒细胞明胶酶相关脂质运载蛋白(NGAL)作为急性肾损伤(AKI)的一种标志物,与冠心病患者疾病的严重程度、不良预后及未来心血管事件的发生相关,是冠心病领域的潜力标志物。本文就NGAL的来源与性质及NGAL与冠状动脉病变严重程度、稳定型冠心病、急性冠脉综合征(ACS)、未来冠心病事件的关系的研究进展做一综述,希望能够为冠心病生物标志物领域的研究提供新的参考方向。

In recent years,the rapid development of cardiac markers has improved the overall level of cardiovascular disease's diagnosis.Research findings have shown that neutrophil gelatinase-associated lipocalin(NGAL),as a marker of acute renal injury(AKI),is closely related to the severity of coronary heart disease,adverse prognosis and the occurrence of future cardiovascular events.NGAL is also a potential marker in coronary heart disease.The purpose of this review is to elucidate the origin and nature of NGAL and the relationship between NGAL and the severity of coronary artery disease,stable coronary heart disease,acute coronary syndrome(ACS)and future coronary heart disease events.And it aims to provide a promising reference direction for the researches of biomarkers in coronary heart disease.