4种动物骨骼的化学成分与生物活性研究进展

Reviews on Chemical Composition and Biological Activity of 4 Types of Animal Bone

动物骨骼在我国传统医药中具有悠久的应用历史和良好的疗效,具备较高的食用价值。骨骼化学成分主要以胶原蛋白、油脂、矿物质及硫酸软骨素等为主,具有抗氧化、抗菌、降血压、免疫调节、促进成骨细胞增殖及治疗类风湿、关节炎、骨质疏松等骨科疾病作用。因此,本文整理了古籍关于羊、牛、马及骆驼4种动物骨骼的来源、性味、作用等领域的记载,并对其近年来报道的化学成分、生物活性及产品概况等方面的研究进展进行综述,以期为副产物-骨骼资源的功能物质进行基础研究、综合利用及开发高附加值骨骼产品提供参考依据。

Animal bone has a long drug application history as well as good curative effect in traditional Chinese medicine and ethnic medicine. It was considered to have high edible value. Bone mainly consisted of collagen, oil, mineral, and chondroitin sulfate with numerous biological activities such as antioxidant activity, antibacterial activity, antihypertensive activity, immunomodulation, osteoblastic proliferation improvement. It also used to treat orthopedic diseases including rheumatoid, arthritis, and loose fractures. The present paper summarized the sources, properties, tastes and functions of 4 kinds of animal bones(sheep, bovine, horse, and camel) from ancient books. The progress on its chemical composition, pharmacological activity, and products was reviewed to provide basis for clarification of its pharmacologically active ingredients, comprehensive utilization, and development of high value bone products.