利奈唑胺联合盐酸氨溴索治疗新生儿重症肺炎的临床研究

Clinical study on ambroxol hydrochloride combined with linezolid in treatment of severe pneumonia in neonates

目的探讨利奈唑胺联合盐酸氨溴索治疗新生儿重症肺炎的临床效果。方法选择咸阳市第一人民医院2017年5月-2019年5月收治的重症肺炎新生儿患者62例,按照随机数字表法分为对照组和观察组,每组各31例。对照组在常规治疗的基础上静脉输注盐酸氨溴索注射液,7.5 mg/次,2次/d。观察组在对照组治疗的基础上联合使用利奈唑胺注射液,按照每8 h10 mg/kg剂量iv。两组连续治疗10~14 d。观察两组患者的临床疗效,比较两组的临床指标和炎症因子水平。结果治疗后,观察组临床总有效率为96.77%,明显优于对照组77.42%(P<0.05)。治疗后,观察组肺部啰音完全消失时间、肺功能和血气分析指标恢复时间、住院时间等指标均明显短于对照组(P<0.05)。治疗后,两组白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤细胞坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均明显降低,转化生长因子β(TGF-β)水平明显升高(P<0.05),且观察组炎症因子水平改善程度明显优于对照组(P<0.05)。结论利奈唑胺联合盐酸氨溴索治疗新生儿重症肺炎后能够明显提高临床疗效,调节血清炎症因子水平,促进抗炎和促炎因子间动态平衡的恢复,改善临床症状,缩短住院时间,效果显著,可推广使用。

Objective To investigate the clinical effect of ambroxol hydrochloride combined with linezolid in treatment of severe pneumonia in neonates.Methods A total of 62 neonates with severe pneumonia in the First People’s Hospital of Xianyang from May 2017 to May 2019 were selected as the study subjects.According to the random number table method,neonates were divided into control and observation groups,and each group had 31 cases.Neonates in the control group were iv administered with Ambroxol Hydrochloride Injection on the basis of conventional treatment at 7.5 mg/time,twice daily.Neonates in the observation group were iv administered with Linezolid Injection on the basis of control group,injected intravenously at a dose of 10 mg/kg every8 h.Two groups were treated continuously for 10-14 d.After treatment,the clinical efficacy in two groups were observed,and the clinical indicators and levels of inflammatory factors in two groups were compared.Results After treatment,the total effective rate in the observation group was 96.77%,which was significantly better than 77.42%of the control group(P<0.05).After treatment,the lung rales disappeared,the recovery time of lung function and blood gas indicators,and the length of hospital stay in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the levels of IL-2,IL-6,TNF-α,and CRP in two groups were significantly decreased,but TGF-βlevels were significantly increased(P<0.05),and the inflammatory factors levels in the observation group were significantly better than those in the control group(P<0.05).Conclusion ambroxol hydrochloride combined with linezolid in treatment of severe pneumonia in newborns can significantly improve the clinical efficacy,regulate the level of serum inflammatory factors,promote the recovery of the dynamic balance between antiinflammatory and pro-inflammatory factors,improve clinical symptoms,and shorten the length of hospital stay,the effect is significant,it can be widely used.