中药定向透药治疗慢性肾脏病3期脾肾气虚证的临床疗效观察

Clinical Effect of Directional Penetration of Traditional Chinese Medicine in Treating Stage 3 of Chronic Kidney Disease by Syndrome of Qi Deficiency of Spleen and Kidney

目的探讨中药定向透药对慢性肾脏病3期脾肾气虚证的疗效。方法将本院收治的慢性肾脏病3期患者76例随机分为对照组和观察组,每组各38例。观察组给予尿毒清颗粒和中药定向透药治疗。对照组给予尿毒清颗粒和中药定向透药模拟剂。连续治疗12周后,比较两组脾肾气虚证症状评分、肾功能、疗效、血清D-二聚体和胱抑素C水平。结果治疗后,观察组脾肾气虚证症状评分、尿素氮、血肌酐、24 h尿蛋白定量和肾小球滤过率明显少于对照组(P<0.01);观察组的总有效率明显高于对照组(P<0.05);治疗后,观察组血清D-二聚体和胱抑素C水平明显低于对照组(P<0.01)。结论中药定向透药治疗慢性肾脏病3期脾肾气虚证疗效显著,且可下调血清D-二聚体和胱抑素C水平。

OBJECTIVE To investigate the clinical efficacy of directional penetration of traditional Chinese medicine in treating stage 3 of chronic kidney disease patients with syndrome of qi deficiency of spleen and kidney.METHODS 37 stage 3 of chronic kidney disease patients admitted to the hospital were divided into the control group and the observation group with 38 cases in each group according to the random number table method.The observation group was orally treated with Niaoduqing granulesand directional penetration of Chinese medicine(20min/time and once every other day).The control group was given with Niaoduqing granules and directional penetration of Chinese medicine simulation agent.After 12 weeks treatment,scores of syndrome of qi deficiency of spleen and kidney,renal function,the efficacy,and serum levels of d-dimer and cystatin C were compared in the two groups.RESULTS After treatment,the scores of syndrome of qi deficiency of spleen and kidney and urea nitrogen,serum creatinine,24 h urine protein quantification,and glomerular filtration rate in the observation group were significantly lower than the control group after treatment(P<0.01).The total effective rate of the observation group was obviously higher than the control group(P<0.05).After treatment,serum levels of d-dimer and cystatin C in the observation group were significantly lower than those in the control group(P<0.01).CONCLUSION The efficacy of directional penetration of traditional Chinese medicine in treating of chronic kidney disease patients with syndrome of qi deficiency of spleen and kidney was significant and down-regulate serum levels of d-dimer and cystatin C.