皮内针疗法联合七味白术散对中心性肥胖糖尿病患者血糖及血清人脂联素、Apelin的影响

Effect of Intradermal Acupuncture Insertion Combined with Qiweibaizhu Powder on Blood Glucose and Serum Adiponectin,and Apelin in Diabetes Patients with Central Obesity

目的探讨皮内针疗法联合七味白术散对中心性肥胖糖尿病患者的疗效及对血糖、血清人脂联素(ADP)及Apelin水平变化的影响。方法选取2017年6月—2018年6月北京市第一中西医结合医院收治的中心性肥胖糖尿病患者120例,按照随机数字表法分为治疗组和对照组,每组60例。对照组给予二甲双胍治疗,治疗组给予皮内针疗法联合七味白术散治疗,15 d为1个疗程,共治疗3个疗程。观察治疗后两组治疗效果及检测治疗前后血糖及血清ADP、Apelin指标。结果治疗组治疗后总有效率显著高于对照组(P<0.05),差异具有统计学意义;治疗后两组ADP表达均高于本组治疗前,Apelin水平均低于本组治疗前(P<0.05),差异具有统计学意义;治疗组治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)及Apelin明显低于对照组,ADP表达高于对照组(P<0.05);对照组出现2例一过性低血糖及6例轻微胃肠道不良反应,而治疗组未出现低血糖反应,仅有2例出现胃肠道不良反应,继续用药后可耐受。结论皮内针疗法联合七味白术散能有效降低中心性肥胖糖尿病血糖及Apelin表达水平,升高血清ADP表达水平,可作为辅助疗法应用于中心性肥胖糖尿病患者的治疗。

Objective To investigate the therapeutic effect of intradermal acupuncture insertion combined with Qiweibaizhu Powder on patients with central obesity and diabetes,and the effect of serum glucose levels,adiponectin(ADP)and Apelin levels on patients.Methods 120 patients with central obesity and diabetes admitted to our hospital were enrolled.The subjects enroll time was from June 2017 to June 2018.They were randomly divided into treatment group(intradermal acupuncture insertion+Qiweibaizhu Powder)and control group(DMBG)(60 cases in each group.15 days for a course of treatment(A total of 3 courses)).Blood glucose,ADP,Apelin were detected and compared between the two groups.Results The clinical efficacy showed that the total effective rate of the treatment group(91.67.%)was significantly higher than that of the control group(83.33%).There was no significant difference in the expression of blood glucose,Apelin and ADP between the treatment group and the control group.The expressions of FPG,2 h PG,HbA1c and Apelin in the treatment group were significantly lower than those in the control group,and the expression of ADP was higher than that in the control group.Conclusions Intradermal acupuncture insertion combined with Qiweibaizhu Powder is effective in the treatment of central obesity diabetes patients,which can effectively reduce blood glucose levels and decrease serum ADP and Apelin expression levels.