摘要
目的分析四川大学华西医院收治系统性红斑狼疮(SLE)患者情况,了解患者地域分布特点及危险因素。方法收集四川大学华西生物医学大数据中心2009年2月至2019年2月无重复确诊SLE患者7144例,分析患者年龄、性别、地域、民族、职业、嗜烟、嗜酒、过敏史、家族史及发病情况等。结果四川大学华西医院SLE患者就诊住院平均年龄(32.67±15.12)岁,高峰年龄为18~<42岁,男女比为1∶7.13,各年龄段患者性别比比较,差异有统计学意义(χ2=160.34,P<0.001);四川省6502例(占91.01%),就诊住院率为7.26/10万,下属21个地级市以眉山、资阳、成都就诊住院率最高,分别为13.97/10万、13.18/10万、12.69/10万,泸州市就诊住院率最低为1.97/10万;其他省市就诊患者人数以西藏最多(21.34%),云南次之(17.29%)。职业分布:农民最多(占24.33%);民族构成中,汉族占95.16%,少数民族以藏族最多,占64.45%。临床首发症状以皮疹,发热,关节肿痛,四肢水肿多见,占48.26%;累及的病变部位主要为肾(46.49%)、肺(30.45%)、肝(11.77%);SLE伴感染患者2127例(占29.77%),其中肺部感染(占69.63%);在既往感染史中,肝炎占2.78%、结核占3.14%。结论SLE患者眉山、资阳、成都就诊住院率最高,相邻省市西藏和云南居首;农民多见;少数民族以藏族为主。SLE病变具隐匿性和多系统性,感染、过敏、嗜烟等因素可能增加SLE的易感性,对不明原因的水肿、皮疹、发热、关节肿痛患者应注意SLE的筛检。
Objective To analyze the situation of patients with systemic lupus erythematosus(SLE)admitted to West China Biomedical Big Data Center of Sichuan University,to understand the geographical distribution characteristics and risk of patients.Methods A total of 7144 patients diagnosed with SLE from February 2009 to February 2019 were collected and analyzed in West China Biomedical Big Data Center of Sichuan University,including age,gender,region,nationality,occupation,smoking,alcohol abuse,allergy history,family history and incidence.Results The average age of SLE patients in West China Hospital of Sichuan University was(32.67±15.12)years old,and the peak age was 18-<42 years old.The ratio of male to female was 1∶7.13,the sex ratio at all age groups was statistically significant(χ2=160.34,P<0.001);Sichuan province had 6502 cases(91.01%),and the average hospitalization rate was 7.26/100,000.Among the 21 prefecture-level cities,Meishan,Ziyang and Chengdu had the highest hospitalization rates was 13.97/100000,13.19/100000,12.69/100000 respectively.The rate of hospitalization in Luzhou City was the lowest at 1.97/100000;In other provinces and cities,Tibet had the highest number of patients(21.34%),followed by Yunnan(17.29%).Among the occupational distribution,farmers were the most(24.33%);Rate of the nation groups,the Han nationality accounted for 95.16%,and the largest number of ethnic minorities were Tibetans which accounted for 64.45%.The first clinical symptoms were rash,fever,joint swelling and pain,and extremity edema,which were more common(48.26%);The most common lesions were kidney(46.49%),lung(30.45),live(11.77);SLE with infection were 2127 patients(29.77%),including pulmonary infection(69.63%);In the past infection history,hepatitis accounted for 2.78%,tuberculosis accounted for 3.14%.Conclusion The incidence of Meishan,Ziyang and Chengdu in SLE patients is the highest;and the neighboring provinces of Sichuan,Tibet and Yunnan had the highest number of patients.Farmers are common;The ethnic minorities are mainly Tibetans.SLE lesions are insidious and multi-systemic,infection,allergy,smoking and other factors may increase susceptibility to SLE.Patients with unexplained edema,rash,fever and joint swelling and pain should pay attention to the screening of SLE.
作者
梅丽春
苏向珠
朱亭西
翟建昭
武永康
MEI Lichun;SU Xiangzhu;ZHU Tingxi;ZHAI Jianzhao;WU Yongkang(Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China;Department of Clinical Laboratory,Zhaotong First People′s Hospital,Zhaotong,Yunnan 657000,China;West China Biomedical Big Data Center Sichuan University,Chengdu,Sichuan 610041,China)
出处
《检验医学与临床》
CAS
2020年第11期1493-1496,1499,共5页
Laboratory Medicine and Clinic
基金
国家老年疾病临床医学研究中心资助课题(Z2018C03)
四川大学华西医院学科卓越发展135工程项目(ZYJC18042)。
关键词
系统性红斑狼疮
就诊住院率
分布
systemic lupus erythematosus
hospitalization rate
distribution