妊娠期高血压与维生素D、微量元素水平的相关性

Correlation between gestational hypertension and serum vitamin D,trace element level

目的探讨血清维生素D、微量元素水平与妊娠期高血压之间的相关性。方法选择乌鲁木齐市新疆医科大学第二附属医院2016年1月-2019年6月定期产检的152例孕妇,分为妊娠期高血压组(50例)、子痫前期组(50例)和正常妊娠组(52例)。采用化学光法测定血清维生素D及微量元素水平,分析以上指标与妊娠期高血压疾病之间的相关性。结果(1)妊娠期高血压组、子痫前期组与正常妊娠组比较,血清维生素D水平均显著降低,妊娠期高血压组与子痫前期组,子痫前期组与正常妊娠组之间维生素D水平差异有统计学意义(P<0.01)。(2)妊娠期高血压组铜水平下降较子痫前期组和正常妊娠组明显,各组间差异有统计学意义(P<0.05);子痫前期组铁水平最高,正常妊娠组最低,妊娠期高血压组和子痫前期组与正常妊娠组铁水平与正常妊娠组比较,差异均有统计学意义(P<0.05);子痫前期组锌水平下降较其他两组更明显,子痫前期组与正常妊娠组锌水平差异有统计学意义(P<0.05);子痫前期组钙水平最低,妊娠期高血压组、子痫前期组与正常妊娠组间差异有统计学意义(P<0.05);子痫前期组镁水平最高,妊娠期高血压组其次,正常妊娠组最低,3组镁水平之间差异有统计学意义(P<0.05)。(3)妊娠期高血压与镁、钙、维生素D水平变化有关,而子痫前期组与镁、铁、铜、钙水平变化有关,其中钙、镁、铜显著性明显。(4)3组维生素D与钙比例子痫前期组最小,3组间差异有统计学意义(P<0.01)。结论妊娠期高血压疾病与维生素D水平下降以及微量元素水平变化有关,尤其是镁、铁、钙、锌等微量元素水平改变可能与妊娠期高血压疾病的发生、发展有关。维生素D与微量元素共同参与妊娠期高血压的发病机制。

Objective To explore the correlation between gestational hypertension and serum 25-hydroxyvitamin D,trace elements.Methods From January 2016 to June 2019,a total of 152 pregnant women in the Second Affiliated Hospital of Xinjiang Medical University were randomly divided into pregnant hypertension group(50 cases),preeclampsia group(50 cases)and normal pregnancy group(52 cases).The levels of 25 hydroxyvitamin D and trace elements in serum were measured by chemical light method,and the correlation between them was analyzed.Results(1)Compared with the normal pregnancy group,the serum vitamin D levels in the pregnant hypertension group and the preeclampsia group were significantly lower than that in the normal pregnancy group(P<0.01).The level of copper in the pregnant hypertension group was significantly lower than those in the preeclampsia group and normal pregnancy group(P<0.05);the iron level in the preeclampsia group was the highest,while that in the normal pregnancy group was the lowest;the iron levels in the pregnant hypertension group and preeclampsia group were statistically significant compared with that in the normal pregnancy group(P<0.05);the zinc level in the preeclampsia group was statistically significant(P<0.05),and the decrease was more significant than the other two groups,the difference of zinc level between the preeclampsia group and the normal pregnancy group was statistically significant(P<0.05);the calcium level in the preeclampsia group was the lowest,and the difference between the pregnant hypertension group,the preeclampsia group and the normal pregnancy group was statistically significant(P<0.05);the magnesium level from high to low was ranking as the preeclampsia group,the pregnant hypertension group,the normal pregnancy group,and the difference between the three groups was statistically significant(P<0.05).(3)Pregnant hypertension was related to the changes of magnesium,calcium and vitamin D levels,while the preeclampsia group was related to the changes of magnesium,iron,copper and calcium levels.(4)The ratio of vitamin D and calcium in the three groups was the lowest in the preeclampsia group,and the difference between the three groups was statistically significant(P<0.01).Conclusion Hypertension in pregnancy is related to the decrease of vitamin D and the change of trace elements,especially the change of magnesium,iron,calcium,zinc and other trace elements,which may be related to the occurrence and development of hypertension in pregnancy.Vitamin D and trace elements are involved in the pathogenesis of pregnancy induced hypertension.