中性粒细胞弹性蛋白酶及与疾病的关系研究进展被引量：11

Research progress on the correlation between neutrophil elastase and related diseases

下载PDF

导出

摘要中性粒细胞弹性蛋白酶(neutrophil elastase,NE)是中性粒细胞分泌的主要丝氨酸蛋白酶之一,其可通过对细胞因子水解活化、细胞受体的加工等方式,参与慢性炎症性疾病如动脉粥样硬化、慢性阻塞性肺疾病、肺囊肿性纤维症等疾病的发生发展。本文主要综述了NE的生物学功能、近年来NE在慢性肺部疾病中的最新作用机制以及NE可能参与的其他相关疾病,期望为相关疾病的防治提供新的思路。 Neutrophil elastase(NE)is one of the major serine proteases secreted by neutrophils,which can participate in the pathogenesis and development of chronic inflammatory diseases including atherosclerosis,chronic obstructive pulmonary diseases,lung cyst fibrosis through cytokine hydrolysis and activation of cell receptors.This article reviews the biological functions of NE,the latest mechanism of NE in chronic lung disease in recent years,and other related diseases in which NE may be involved.It is expected to provide new ideas for the prevention and treatment of related diseases.

作者赵曰霞邓莉 ZHAO Yuexia;DENG LI(Department of Parasitology and Cinical Parasite Test,Guangdong Medical University,Guangdong,Zhanjiang 524023,China)

机构地区广东医科大学寄生虫学及临床寄生虫检验

出处《河北医药》 CAS 2020年第11期1729-1733,共5页 Hebei Medical Journal

基金国家自然科学基金(编号:31101639)。

关键词弹性蛋白酶炎症性疾病组织蛋白动脉样硬化慢性阻塞性肺疾病肺囊肿型纤维化 elastase inflammatory diseases tissue protein arteriosclerosis chronic obstructive pulmonary disease pulmonary cystic fibrosis

分类号 R363.1 [医药卫生—病理学]

引文网络
相关文献

参考文献1

1邓振,何庆丰,彭礼飞.中性粒细胞丝氨酸蛋白酶及其抑制剂与炎症[J].中国药理学通报,2014,30(3):18-21. 被引量：16

二级参考文献30

1Heutinck K M,ten Berge I J,Hack C E,et al.Serine proteases of the human immune system in health and disease[J].Mol Immunol,2010,47(11-12):1943-55.
2Steven S D.Neutrophil elastase:path clearer,pathogen killer,or just pathologic[J]-.Am J Respir Cell Mol Biol,2002,26(3):266-8.
3Jochum M,Gippner-Steppert C,Machledit W,et al.The role of phagocyte proteinases and proteinase inhibitors in multiple organ failure[J].Am J Respir Crit Care Med,1994,150 (6 Pt 2):S123-30.
4Burster T,Macmillan H,Hou T,et al.Cathepsin G:roles in antigen presentation and beyond[J].Mol Immunol,2010,47:658-65.
5Gregory A D,Houghton A M.Tumor-associated neutrophils:new targets for cancer therapy[J].Cancer Res,2011,71(7):2411-6.
6Hajjar E,Broemstrup T,Kantari C,et al.Structures of human proteinase 3 and neutrophil elastase-so similar yet so different[J].FEBS J,2010,277(10):2238-54.
7Perera N C,Schilling O,Kittel H,et al.NSP4,an elastase-related protease in human neutrophils with arginine specificity[J].Proc Natl Acad Sci USA,2012,109(16):6229-34.
8Perera N C,Jenne D E.Perspectives and potential roles for the newly discovered NSP4 in the immune system[J].Expert Rev Clin Immunol,2012,8(6):501-3.
9Chalmers J D,Hill A T.Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis[J].Mol Immunol,2013,55(1):27-34.
10Lucas S D,Costa E,Guedes R C,et al.Targeting COPD:advances on low-molecular-weight inhibitors of human neutrophil elastase[J].Med Res Rev,2013,33(Suppl 1):E73-101.