为联用二甲双胍和吡格列酮疗效不佳的2型糖尿病患者用利格列汀进行治疗的效果

Treatment with ligrettin for type 2 diabetic patients who did not respond well to metformin and pioglitazone

目的:探讨为联用盐酸二甲双胍和盐酸吡格列酮疗效不佳的2型糖尿病患者应用利格列汀进行治疗的效果.方法:选取2017年2月至2018年11月在成都市新都区人民医院联用盐酸二甲双胍和盐酸吡格列酮进行治疗效果不佳的60例2型糖尿病患者作为研究对象.将其随机分为甲组(n=30)和乙组(n=30).使用安慰剂对甲组患者进行治疗.使用利格列汀对乙组患者进行治疗.然后,比较两组患者的胰岛素抵抗指数、糖化血红蛋白、空腹血糖、餐后2小时血糖的水平及不良反应的发生情况.结果:治疗后,乙组患者的胰岛素抵抗指数小于甲组患者,P<0.05;乙组患者糖化血红蛋白、空腹血糖、餐后2小时血糖的水平及不良反应的总发生率均低于甲组患者,P<0.05.结论:使用利格列汀对联用盐酸二甲双胍和盐酸吡格列酮治疗效果不佳的2型糖尿病患者进行治疗,可取得理想的临床效果,有效控制其血糖的水平.

Objective:To investigate the therapeutic effect of ligrettin in combination with metformin hydrochloride and pioglitazone hydrochloride in type 2 diabetes patients with poor efficacy.Methods:60 patients with type 2 diabetes who were treated with metformin hydrochloride and pioglitazone hydrochloride in xindu district people’s hospital of chengdu from February 2017 to November 2018 were selected as subjects.They were randomly divided into group a(n=30)and group b(n=30).Group a patients were treated with placebo.Patients in group b were treated with ligrelitine.Then,the insulin resistance index,glycosylated hemoglobin,fasting blood glucose,blood glucose level 2 hours after meal and the occurrence of adverse reactions were compared between the two groups.Results:after treatment,the insulin resistance index of group b was lower than that of group a,P<0.05.The total incidence of hba1c,fasting blood glucose,2 h postprandial blood glucose and adverse reactions in group b were all lower than those in group a,P<0.05.Conclusion:in patients with type 2 diabetes who are not well treated with metformin hydrochloride and pioglitazone hydrochloride,ligrettin can achieve ideal clinical results and effectively control their blood glucose levels.