溶瘤病毒调控肿瘤微环境及联合治疗的研究进展

Advances on The Regulation of Tumor Microenvironment and Combination Therapy by Oncolytic Viruses

溶瘤病毒是一类天然的或经改造后获得具有靶向杀伤癌细胞能力的病毒,除了能特异性杀伤肿瘤细胞外,经改造后的溶瘤病毒对肿瘤微环境的调控作用也会影响其最终疗效.通过调控肿瘤微环境中肿瘤细胞抗原的表达、免疫抑制状态、肿瘤相关成纤维细胞及肿瘤血管新生等,溶瘤病毒为肿瘤的治疗提供了更为系统的治疗策略;联合免疫检查点抑制剂的使用能使两者获得协同和互补的功效,进一步提升了肿瘤全面和有效的治疗.本文将对溶瘤病毒对肿瘤微环境调控作用及联合治疗的研究进展进行综述.

Oncolytic viruses(OVs) are a type of natural or engineered viruses that preferentially target cancer cells. The engineered OVs can not only target cancer cells, but also regulate the tumor microenvironment which will have some effects on the therapeutic efficacy consequently. Oncolytic viruses are emerging as a system therapeutic strategies by modulating the expression of tumor antigens, immunosuppressive state, tumor-associated fibroblasts and angiogenesis in the tumor microenvironment. Moreover, the combination of OVs and immune checkpoint inhibitor can achieve very good synergistic and complementary effects. This paper summarized the progress of OVs on tumor microenvironment and combination therapy with immune checkpoint inhibitor.