乳腺癌组织中THRSP蛋白表达及临床意义

THRSP Protein Expression in Breast Cancer Tissues and Its Clinical Significance

目的探讨THRSP蛋白在人类乳腺癌组织中的表达及临床意义。方法选取102例乳腺癌患者,取本组患者的石蜡标本,采用SP法对乳腺癌组织以及癌旁组织中的THRSP蛋白表达进行检测,对本组患者的临床资料进行整理,观察并分析THRSP蛋白表达与患者雌雄受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER-2)的表达以及基因分型、临床分期、淋巴结转移率、组织学分级的关系。结果THRSP蛋白阳性表达主要定位于细胞核,细胞质有少量的表达。乳腺组织中THRSP蛋白阳性表达率为56.86%(58/102),高于癌旁组织中THRSP蛋白阳性表达率3.92%(4/102),差异明显(P<0.05);乳腺组织中THRSP蛋白的异常高表达与组织学分级有关,与患者的年龄、原发肿瘤的大小、ER、PR、HER-2状态、基因分型、临床分期、淋巴结转移等无关。结论乳腺癌组织中THRSP蛋白的阳性表达高于正常乳腺组织中的THRSP蛋白阳性表达,并且乳腺组织学分级越高,患者的THRSP蛋白阳性表达越高。

Objective To explore the expression and clinical significance of THRSP protein in human breast cancer tissue.Methods 102 patients with breast cancer were selected,paraffin samples from the tissues of patients were extracted,SP method was used to detect THRSP protein expression in breast cancer tissues and adjacent tissues,clinical data of the patient was organized,The relationship between expression of THRSP protein and both expression of male and female receptors(ER),rogesterone receptor(PR)and human epidermal growth factor receptor 2(her-2),and genotype,clinical stage,lymph node metastasis rate,histological grade was observed and analyzed.Results The expression of THRSP protein was mainly localized in the nucleus,and the cytoplasm of that had a small amount of expression.The positive expression rate of THRSP protein of breast tissues was 56.86%(58/102),which was higher than that of the paracancer tissues by 3.92%(4/102)(P<0.05).The abnormally high expression of THRSP in breast tissue was associated with histological grading,but which was independent of patient's age,primary tumor size,ER,PR,her-2 status,genotype,clinical stage,lymph node metastasis and other factors.Conclusion The positive expression of THRSP protein in breast cancer tissue is higher than that in normal breast tissue,and the higher the histological grade of breast,the higher the positive expression of THRSP protein in patients.