微创经皮椎体成形术联合射频消融术治疗脊柱转移性肿瘤的疗效及对患者CRP水平的影响

Effect and Its Influence on the Level of CRP in the Treatment of Patients with Spinal Metastatic Tumor by Using Minimally Invasive Percutaneous Vertebroplasty Combined with Radiofrequency Ablation

目的探究微创经皮椎体成形术联合射频消融术(RFA)治疗脊柱转移性肿瘤的疗效及对患者C-反应蛋白(CRP)水平的影响。方法选取脊柱转移性肿瘤患者220例,按照治疗方式分为对照组和观察组,分别70例和150例。对照组患者进行微创经皮椎体成形术,观察组患者在此基础上进行RFA治疗。观察并分析2组患者疼痛情况、CRP水平、生活质量及治疗总有效率。结果观察组患者治疗总有效率为88.0%,显著高于对照组的58.6%,差异具有统计学意义(P<0.05)。观察组患者术后1 d、术后5 m视觉模拟疼痛评分(VAS)均低于对照组,差异具有统计学意义(P<0.05);观察组患者术后7 d、术后2 m、术后5 m的疼痛缓解总有效率均显著高于对照组,差异有统计学意义(P<0.05);观察组患者术后24 h、48 h CRP水平均显著低于对照组,差异有统计学意义(P<0.05);术后5 m,2组患者ODI评分均降低,观察组明显低于对照组,差异具有统计学意义(P<0.05)。结论微创经皮椎体成形术联合RFA能够有效改善脊柱转移性肿瘤患者的疼痛情况、脊髓功能,降低机体炎症反应,提高患者生活质量。

Objective To investigate the effect and its influence on the level of C-reactive protein(CRP)in the treatment of patients with spinal metastatic tumor by using minimally invasive percutaneous vertebroplasty combined with radiofrequency ablation(RFA).Methods 220 patients with spinal metastatic tumor were selected and divided into the control group and the observation group according to treatment methods,with 70 cases and 150 cases respectively.The control group was treated with minimally invasive percutaneous vertebroplasty,and the observation group was treated with RFA on this basis.The pain,the level of CRP,quality of life and the total effective rate of treatment were observed and analyzed between the 2 groups.Results The total effective rate in the observation group was 88.0%,which was significantly higher than that of the control group(58.6%,P<0.05).The score of visual analogue scale(VAS)in the observation group was lower than that of the control group at 1d and 5m after operation(P<0.05).The total effective rate of pain relief in the observation group was significantly higher than that in the control group at 7 days,2m and 5m after operation(P<0.05).The levels of CRP at 24h and 48h after operation in the observation group were significantly lower than those of the control group(P<0.05).At 5m after operation,the score of ODI in the two groups all decreased,and that in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Minimally invasive percutaneous vertebroplasty combined with RFA can effectively improve the pain and spinal cord function of patients with spinal metastatic tumors,reduce the inflammatory response and improve the quality of life of patients.