甲状腺癌不同治疗方法彩超声像学改变和sIL-2R的相关性

Correlation between Color Ultrasonographic Changes and sIL-2R in Different Treatment Methods for Thyroid Cancer

目的分析甲状腺癌不同治疗方法彩超声像学改变与sIL-2R的相关性。方法选择收治100例甲状腺癌患者,根据不同治疗方法将患者分为对照组与观察组,每组50例。对照组使用传统手术,观察组使用低领小弧形切口,对比两组彩超声像学改变和sIL-2R相关性。选择同年体检50例健康人员作为健康组,与甲状腺癌患者对比不同甲状腺疾病的血清sIL-2R。结果两组患者治疗前sIL-2R水平无差异,观察组患者治疗第5天的sIL-2R含量比治疗前高,治疗后第10天开始下降,第30 d降到正常情况,观察组患者治疗后的sIL-2R水平比对照组改善明显(P<0.05),观察组患者的切口长度比对照组短,出血量比对照组少,满意率比对照高,生存率与复发率比对照组低(P<0.05);所有甲状腺癌患者治疗后,甲状腺中回声均匀和境界清楚例数有所增加,回声不均匀与边界不清楚例数降低,治疗后血清sIL-2R第5天就开始降低,之后两者没有明显差异(P>0.05);甲状腺手术之前的血清sIL-2R比良性和健康组高(P<0.05),之后两者没有明显差异(P>0.05)。结论在对甲状腺癌治疗过程中,低领小弧形切口治疗能够改善sIL-2R,提高患者治疗效果,值得临床推广使用。

Objective To analyze the correlation between color ultrasonographic changes and sIL-2R in different treatment methods for thyroid cancer.Methods 100 patients with thyroid cancer were selected.According to different treatment methods,the patients were divided into the control group and the observation group,with 50 patients in each group.The control group were treated with conventional surgery,while the observation group were treated with low-collar small arc incision,the correlation between color ultrasound changes and sIL-2R in the 2 groups was compared.50 healthy patients were selected as health group,who and thyroid cancer patients were compared with serum sIL-2R of different thyroid diseases.Results sIL-2R level before treatment was not different between the 2 groups,patients in the observation group,sIL-2R content was higher on the 5th day after treatment than before treatment,began to decline on the 10th day after treatment,and returned to normal on the 30th day,the sIL 2R level of the observation group was significantly improved after treatment compared with that of the control group(P<0.05).Patients in the observation group had shorter incision length,less blood loss than the control group,higher satisfaction rate than the control group,lower survival rate and recurrence rate than the control group(P<0.05);After treatment,the number of cases with uniform echo and clear boundary in thyroid gland increased,while the number of cases with uneven echo and unclear boundary decreased.Serum sIL-2R began to decrease on the 5th day after treatment,and there was no significant difference between the 2 groups after treatment(P>0.05).Serum sIL-2R before thyroid surgery was higher than that in benign and healthy groups(P<0.05),there was no significant difference between the 2 groups after thyroid surgery(P>0.05).Conclusion In the treatment of thyroid cancer,the treatment of low-collar small arc incision can improve sIL-2R and the treatment effect of patients,which is worthy of clinical promotion.