局部麻醉药长效递送系统的开发及其在术后镇痛中的应用进展

Progress in Development of Long-acting Delivery Systems for Local Anesthetics and Its Application in Postoperative Analgesia

患者在手术后需要适当的疼痛缓解。应用局部麻醉药进行局部神经阻滞控制术后的急、慢性疼痛,但因作用持续时间短和心脏、神经毒性等缺点,其临床应用受到限制。局部麻醉药长效递送系统可在局部持续和控制释放药物,延长药物作用时间的同时降低药物的副作用,为长期术后镇痛方案奠定了基础。笔者综述了局部麻醉药长效递送系统的研究现状和存在的问题,并探讨了局部麻醉药长效制剂研究中应重点关注的问题。

Patients require proper pain relief after surgery.Local anesthetics are widely used to control postoperative pain,but their clinical application is limited due to short duration of action.In decades of research,the long-acting delivery systems have been applied to local anesthetics,with the purpose of locally and continuously release drugs to prolong the action of drugs and reduce the side effects.The study of local anesthetics long-acting delivery systems has laid foundation for clinical postoperative analgesia.This paper reviewed the research status of long-acting drug delivery systems for local anesthetics,and discussed the advantages and existing problems.