针刺拔罐发泡疗法对支气管哮喘患者气道阻力与血清非对称二甲基精氨酸的影响

Effects of Acupuncture and Cupping Blistering Therapy on Airway Resistance and Serum Asymmetric Dimethylarginine in Bronchial Asthma Patients

目的观察针刺拔罐发泡疗法对支气管哮喘患者气道阻力与血清非对称二甲基精氨酸(ADMA)的影响。方法选择114例支气管哮喘急性发作期患者,采用随机数字表法将患者分为对照组和观察组,每组57例。对照组给予西医常规治疗,观察组在对照组基础上给予针刺拔罐发泡疗法,观察两组治疗前后气道阻力(Rint)、第1秒用力呼气容积(FEV1)、呼气流量峰值(PEF)、ADMA水平、呼出气一氧化氮(FeNO)水平,观察两组临床疗效。结果治疗后两组患者Rint、FeNO水平与治疗前比较均显著降低(P<0.05),且观察组低于对照组(P<0.05);治疗后两组FEV1、PEF、ADMA水平与治疗前比较均显著升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后两组中医证候积分与治疗前比较均显著降低(P<0.05),且观察组低于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05)。结论在常规药物治疗基础上,针刺拔罐发泡疗法可改善支气管哮喘急性期患者肺功能,降低患者气道阻力,提高临床治疗效果,提高内源性ADMA水平,从而抑制诱导型一氧化氮合酶活性,可能是其重要作用机制。

Objective To observe the effects of acupuncture and cupping blistering therapy on the airway resistance and serum Asymmetric dimethylarginine(ADMA)in bronchial asthma patients.Method A total of 114 patients with bronchial asthma in acute attack were recruited and divided into a control group and an observation group using the random number table method,with 57 cases in each group.The control group was given routine Western medication treatment,based on which,the observation group was given acupuncture and cupping blistering therapy.The airway resistance(Rint),forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),the ADMA level,and fractional exhaled nitric oxide(FeNO)were observed before and after treatment in the two groups,and the clinical efficacy was also observed.Result The Rint and FeNO levels declined significantly after treatment in both groups(P<0.05),and were lower in the observation group than in the control group(P<0.05);the FEV1,PEF and ADMA levels increased significantly after treatment in both groups(P<0.05),and were higher in the observation group than in the control group(P<0.05).The TCM syndrome and symptom score dropped significantly after treatment in the two groups(P<0.05),and was lower in the observation group than in the control group(P<0.05).The total effective rate was higher in the observation group than in the control group(P<0.05).Conclusion Based on the conventional medication treatment,Acupuncture plus cupping blistering therapy can improve the pulmonary function,reduce airway resistance and enhance clinical efficacy in treating patients with bronchial asthma in acute stage,and up-regulating the endogenous ADMA level to inhibit the inducible nitric oxide synthase(iNOS)activity may be its key action mechanism.