皮内注射曲安奈德与超声导入多磺酸粘多糖乳膏治疗增生性瘢痕的疗效对比

Comparison of the Therapeutic Effect of Intradermal Injection of Triamcinolone and Ultrasound-Induced Mucopolysaccharide Polysulfate Cream for the Treatment of Hypertrophic Scars

目的对比分析曲安奈德联合压力疗法治疗增生性瘢痕的临床疗效。方法选取2017年1月至2019年1月许昌市中医院收治的82例增生性瘢痕患者作为研究对象,并按照随机数表法随机分为观察组(41例)与对照组(41例),其中观察组患者采用皮内注射曲安奈德联合压力疗法治疗,对照组患者采用超声导入多磺酸粘多糖乳膏联合压力疗法治疗,对比两组患者治疗前后温哥华瘢痕量表(Vancouver scar scale,VSS)评分及视觉模拟评分法(visual analogue scale,VAS)评分变化情况。结果治疗后,两组患者VSS评分及VAS评分均明显低于治疗前(观察组:t=12.420、9.357,P均=0.000;对照组:t=8.779、4.859,P均=0.000),且观察组明显低于对照组(t=3.252、2.690,P=0.002、0.009)。结论与超声导入多磺酸粘多糖乳膏联合压力疗法相比,皮内注射曲安奈德联合压力疗法更有利于缓解瘢痕疼痛,改善瘢痕色泽、质地及血液循环,具有较高的临床应用价值。

Objective To comparatively analyze the therapeutic effect of triamcinolone combined with pressure therapy in treating hypertrophic scars.Methods Eighty-two patients with hypertrophic scars,admitted to Xuchang TCM Hospital from January 2017 to January 2019,were selected as research subjects and then divided,according to random number table,into an observation group(41 cases) and a control group(41 cases).Patients in the observation group were treated with intradermal injection of triamcinolone combined with pressure therapy while patients in the control group were treated with ultrasound-induced mucopolysaccharide polysulfate(MPS) cream combined with pressure therapy.The changes of the Vancouver scar scale(VSS) score and visual analogue scale(VAS) score before and after treatment were compared between the two groups.Results After treatment,the VSS score and VAS score of the two groups were significantly lower than before treatment(observation group:t=12.420,9.357,all P=0.000;control group:t=8.779,4.859,all P=0.000),and the scores of the observation group was significantly lower than the control group(t=3.252,2.690,P=0.002,0.009).Conclusion Compared with ultrasound-introduced MPS cream combined with pressure therapy,intradermal injection of triamcinolone combined with pressure therapy has better effect in relieving scar pain,improving scar color,texture and blood circulation and has higher clinical application value.