摘要
年龄相关性黄斑变性(age-related macular degeneration,AMD)是一种严重损害视力的进行性眼病,是导致失明的重要原因之一。近年来有大量研究发现,遗传因素与AMD的发生发展有着明显的相关性。基因多态性的研究为临床诊断和治疗提供了新的思路和方向。本文将与补体因子H(CFH)基因、丝氨酸蛋白酶(HTRA1)基因、年龄相关性黄斑变性易感因子2(ARMS2)基因、血管内皮生长因子(VEGF)基因单核苷酸多态性(single-nucleotide polymorphisms,SNP)相关的研究进展做一简单的综述。
Objective:Age-related macular degeneration(AMD)is a kind of progressive eye disease that seriously damages vision,and it is one of the important causes of blindness.In recent years,a large number of studies have found that there is a significant correlation between genetic factors and the occurrence and development of AMD.The study of gene polymorphism provides new ideas and directions for clinical diagnosis and treatment.This paper makes a brief review of the research progress related to complement factor H(CFH),serine protease(HtrA1),age-related macular degeneration susceptibility factor 2(ARMS2)and vascular endothelial growth factor(VEGF)gene single nucleotide polymorphisms(SNP).
作者
晏鑫
李凌
关瑞娟
YAN Xin;LI Ling;GUANG Rui-juan(Qinghai University,Xining,Qinghai 810000,China;Department of Ophthalmology,Qinghai Provincial People's Hospital,Xining,China)
出处
《海南医学院学报》
CAS
2020年第11期871-875,共5页
Journal of Hainan Medical University
基金
青海省科技厅资助项目(2017-ZJ-756).
关键词
年龄相关性黄斑变性
基因多态性
高海拔地区
研究进展
Age related macular degeneration
Gene polymorphism
High altitude area
Research progress