高浓度血浆血小板衍生生长因子C对冠心病患者冠状动脉病变的影响

Effect of high concentration plasma platelet-derived growth factor-C on coronary artery disease in patients with coronary heart disease

目的探究血浆血小板衍生生长因子C(PDGF-C)浓度变化与冠心病及冠状动脉病变程度的关系。方法选择行冠状动脉造影住院的急性冠状动脉综合征(ACS)患者52例、稳定型心绞痛(SAP)患者52例,以及造影结果正常的其他患者为对照组50例。冠心病(ACS和SAP)患者中冠状动脉多支病变者60例,双支病变者25例,单支病变者19例。酶联免疫吸附试验(ELISA)法测定各组患者血浆PDGF-C浓度。比较各组间血浆PDGF-C浓度水平,并进行Spearman相关性分析、Logistic回归分析及绘制ROC曲线。结果ACS组及SAP组血浆PDGF-C浓度比对照组高(P<0.05)。冠状动脉多支及双支病变组血浆PDGF-C浓度比单支病变组高(P<0.05)。Spearman相关性分析发现,血浆PDGF-C浓度与Gensini评分有一定相关性(r=0.218,P<0.05)。Logistic回归分析发现,高浓度血浆PDGF-C相比于低浓度血浆PDGF-C,患者发生冠心病的风险增加(OR=1.006,95%CI 1.002~1.011)。血浆PDGF-C浓度的ROC曲线下面积为0.645,灵敏度为77.88%。结论高浓度血浆PDGF-C可能是冠心病发病的危险因素,与冠状动脉病变的严重程度可能存在一定的关联。

Aim To research the connection between the changes of plasma platelet-derived growth factor C(PDGF-C)concentration and coronary heart disease and the degree of coronary artery disease.Methods The research includes 52 patients with acute coronary syndrome(ACS),52 patients with stable angina pectoris(SAP),and 50 patients with normal angiography as the control group.Among patients with coronary heart disease(ACS and SAP),there were 60 cases of coronary artery multivessel disease,25 cases of double vessel disease,and 19 cases of single vessel disease.The enzyme-linked immunosorbent assay(ELISA)method was used to determine the plasma PDGF-C concentration in each group of patients.The plasma PDGF-C concentration levels were compared between groups,and Spearman correlation analysis,Logistic regression analysis,and ROC curve were drawn.Results The concentration of PDGF-C in the ACS group and the SAP group was higher than that in the control group(P<0.05).The plasma PDGF-C concentration in the multivessel and double disease groups was higher than that in the single disease group(P<0.05).The results of Spearman correlation analysis indicated that there was a correlation between plasma PDGF-C concentration and Gensini score(r=0.163,P<0.05).Logistic regression analysis found that patients with high concentration of PDGF-C had a higher risk of coronary heart disease than patients with low concentration of PDGF-C(OR=1.006,95%CI 1.002~1.011).The area under the ROC curve of plasma PDGF-C concentration was 0.645,and the sensitivity was 77.88%.Conclusion High-concentration plasma PDGF-C may be a risk factor for coronary heart disease and may be related to the severity of coronary artery disease.