盐酸米诺环素软膏联合甲硝唑药膜治疗牙周病的临床研究

Clinical study of minocycline hydrochloride ointment combined with metronidazole membrane in the treatment of periodontal disease

目的研究盐酸米诺环素软膏联合甲硝唑药膜治疗牙周病的临床疗效。方法900例牙周病患者,随机分为观察组和对照组,每组450例。对照组患者采用甲硝唑药膜治疗,观察组患者对照组基础上增加盐酸米诺环素软膏治疗。比较两组患者临床疗效以及牙周相关指标(出血指数、牙周袋深度、牙龈指数、牙菌斑指数、牙周附着水平、牙齿坚固指数)。结果观察组治疗总有效率93.56%高于对照组的74.67%,差异具有统计学意义(P<0.05)。观察组患者出血指数(0.69±0.12)、牙周袋深度(2.48±0.36)mm、牙龈指数(0.56±0.09)、牙菌斑指数(0.52±0.10)、牙周附着水平(0.75±0.16)、牙齿坚固指数(3.65±0.85)均低于对照组的(1.26±0.39)、(3.05±0.55)mm、(0.86±0.22)、(0.72±0.29)、(1.46±0.39)、(4.62±1.35),差异均具有统计学意义(P<0.05)。结论采用盐酸米诺环素联合甲硝唑治疗牙周病疗效确切,可显著改善患者的牙周相关指标,具有提升牙周附着,减少出血等功效,能够快速缓解患者病情,值得推广。

Objective To study the clinical efficacy of minocycline hydrochloride ointment combined with metronidazole membrane in the treatment of periodontal disease.Methods A total of 900 patients with periodontal disease were randomly divided into observation group and control group,with 450 cases in each group.The control group was treated by metronidazole membrane,and the observation group was treated by minocycline hydrochloride ointment on the basis of the control group.The clinical efficacy,periodontal related indicators(bleeding index,periodontal pocket depth,gingival index,plaque index,periodontal attachment level,tooth firmness index)were compared between the two groups.Results The total effective rate of treatment 93.56%of the observation group was higher than that of the control group 74.67%,and the difference was statistically significant(P<0.05).The bleeding index(0.69±0.12),periodontal pocket depth(2.48±0.36)mm,gingival index(0.56±0.09),plaque index(0.52±0.10),periodontal attachment level(0.75±0.16)and tooth firmness index(3.65±0.85)of the observation group were lower than those of the control group(1.26±0.39),(3.05±0.55)mm,(0.86±0.22),(0.72±0.29),(1.46±0.39)and(4.62±1.35),and the difference was statistically significant(P<0.05).Conclusion Minocycline hydrochloride ointment combined with metronidazole membrane shows affirmative efficacy in the treatment of periodontal disease,which can significantly improve the periodontal related indicators,with the effect of improving periodontal attachment,reducing bleeding,thus quickly relieving the patient’s condition.It is worth promoting.