复方苦参注射液辅助放疗治疗肺癌的疗效分析及评估

Analysis and evaluation of the therapeutic effect of compound Kushen injection in the treatment of lung cancer

目的探讨复方苦参注射液辅助放疗治疗肺癌的疗效。方法80例肺癌患者,随机分为观察组和对照组,每组40例。对照组单纯使用放疗治疗,观察组使用复方苦参注射液辅助放疗治疗。比较两组临床疗效、毒副反应发生情况以及治疗前后血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL-6)、转化生长因子-β1(TGF-β1)、血小板源性生长因子(PDGF)]水平、癌症患者生活质量测定量表核心量表(QLQ-C30)评分。结果观察组治疗总有效率60.00%、疾病控制率87.50%均高于对照组的37.50%、67.50%,差异具有统计学意义(P<0.05)。观察组胃肠道反应、骨髓抑制、放射性食管炎、放射性肺炎发生率分别为37.50%、42.50%、20.00%、17.50%,均低于对照组的70.00%、72.50%、42.50%、37.50%,差异具有统计学意义(P<0.05)。治疗后1、3个月,观察组患者的TNF-α、IL-6、TGF-β1、PDGF水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后3个月,观察组躯体、认知、情绪、角色、社会功能评分分别为(66.72±4.73)、(71.68±6.24)、(59.24±5.52)、(65.37±5.46)、(60.76±5.35)分,均高于对照组的(60.89±4.51)、(67.23±5.92)、(53.67±5.19)、(60.41±4.87)、(55.23±4.58)分,差异均具有统计学意义(P<0.05)。结论与单纯放疗比较,复方苦参注射液辅助放疗治疗肺癌的疗效显著,能提升对肿瘤的抑制效果,减少放疗所致毒副反应,抑制机体炎症反应,提高了生活质量,具有积极的临床意义。

Objective To discuss the efficacy of compound Kushen injection-assisted radiotherapy for lung cancer.Methods A total of 80 lung cancer patients were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated by radiotherapy,and the observation group was treated by compound Kushen injection-assisted radiotherapy.The clinical efficacy,occurrence of toxic and side effects,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin(IL-6),transforming growth factor-β1(TGF-β1),platelet-derived growth factor(PDGF)]levels and quality of life questionarycore 30(QLQ-C30)score before and after treatment were compared between the two groups.Results The total effective rate of treatment 60.00%and disease control rate 87.50%of the observation group were all higher than those of the control group 37.50%and 67.50%,and the difference was statistically significant(P<0.05).The incidence of gastrointestinal reactions,bone marrow suppression,radiation esophagitis,radiation pneumonitis of the observation group were 37.50%,42.50%,20.00%and 17.50%respectively,which were all lower than those of the control group 70.00%,72.50%,42.50%and 37.50%,and the difference was statistically significant(P<0.05).1 and 3 months after treatment,the levels of TNF-α,IL-6,TGF-β1 and PDGF of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).3 months after treatment,the scores of body,cognition,emotion,role and social function of the observation group were(66.72±4.73),(71.68±6.24),(59.24±5.52),(65.37±5.46)and(60.76±5.35)points,which were all higher than those of the control group(60.89±4.51),(67.23±5.92),(53.67±5.19),(60.41±4.87)and(55.23±4.58)points,and the difference was statistically significant(P<0.05).Conclusion Compared with radiotherapy alone,compound Kushen injection-assisted radiotherapy has a significant effect on the treatment of lung cancer,which can improve the inhibitory effect on tumors,reduce the side effects caused by radiotherapy,suppress the body’s inflammatory response,improve the quality of life,and have positive clinical significance.