基于知识图谱的冠状病毒治疗可视化分析

Visualization analysis on treatment of coronavirus based on knowledge graph

目的:基于知识图谱进行可视化分析,探讨冠状病毒治疗领域研究进展。方法:检索科学网(Web of Science)核心合集数据库建库至2020年2月15日发布的冠状病毒治疗领域相关文献。利用Web of Science数据库文献分析工具统计年度发文趋势,采用VOSviewer软件进行国家、研究机构、作者关系分析及主题词聚类和密度分析;采用HistCite软件筛选重要文献并绘制热点演进进程;采用CiteSpace软件进行主题词爆发点分析,挖掘冠状病毒治疗领域的前沿和热点。结果:共检索到1747条数据,排除17条重复数据,最终纳入1730条数据进入可视化分析。发文量分析显示,冠状病毒治疗领域相关文献在2003年和2012年后均出现上升,从2014年开始发文量维持在高位。国家分布显示,开展冠状病毒治疗研究的国家主要为美国(613篇)、中国(582篇)、德国(122篇)、加拿大(99篇)等,且各国之间合作密切。研究机构分布显示,在冠状病毒治疗领域中国科学院发文量位居榜首(82篇),中国香港大学(74篇)、中国香港中文大学(58篇)紧居其后,其次是美国国家过敏和传染病研究所(37篇);且各机构之间合作密切。作者分布显示,高产作者美国有2位(Ralph S.Baric 21篇、Kuochen Chou 17篇),中国有2位(Yuen Kwok-yung 17篇、Jiang Shibo 16篇),荷兰有1位(Eric J.Snijder 17篇);作者聚类分析显示,冠状病毒治疗领域研究者关注的课题主要集中在反向遗传学、呼吸道感染、受体结合结构域等方面,且所属团队成员相互协作,团队间交流密切。高被引论文分析显示,冠状病毒治疗领域被引频次TOP 15论文主要来自于中国、美国、荷兰等国家;文献内容代表不同时期该领域前沿及热点,研究热点主要为阻止病毒吸附、抑制病毒基因的核酸复制、转录和翻译等;主题词主要分为三大类,即冠状病毒流行病学、基础研究及药物开发,其中基础研究与药物开发关联性较强;关键词爆发点分析显示,1991、1996、2002年分别出现时间相关性爆发点,并且以"诊断""序列"为持续热点。结论:通过知识图谱可视化分析能较好地反映冠状病毒治疗领域研究的发展趋势和热点。目前冠状病毒治疗领域受重视程度呈现周期性改变,与不同时期的新型冠状病毒暴发相关,国家、研究机构、作者间密切联系,治疗热点集中于阻止病毒吸附、抑制病毒基因的核酸复制、转录和翻译等方面,并以此开发药物新靶点。

Objective To discuss the research progress in the field of coronavirus(CoVs)treatment based on the visualization analysis of knowledge graph.Methods The related literatures in the field of CoVs treatment were retrieved from the establishment of Web of Science core collection database to February 15th,2020,and the literature analysis tool of Web of Science database was used to count the annual trend of published literatures.The VOSviewer software was used to analyze the relationship among countries,institutions,authors,clustering and density of subject words.The HistCite software was used to screen important documents and to draw the evolution process of hot spots.The CiteSpace software was used to analyze the breakout points of subject words,so as to find the front and hot spots in this field.Results A total of 1747 data were retrieved,with the exception of 17 duplicate data,and 1730 data were retained for visualization analysis.In terms of literature volume,the literatures on CoVs therapy rose after 2003 and 2012,and the number of published literatures had remained high since 2014.In terms of countries,the main countries that carried out the research on the treatment of CoVs were the United States(n=613),China(n=582),Germany(n=122),Canada(n=99),etc.,and the cooperation among countries was close.In terms of institutions,the number of papers issued by Chinese Academy of Sciences in the field of CoVs treatment ranked first(n=82),followed by University of Hong Kong of China(n=74)and Chinese University of Hong Kong of China(n=58),followed by National Institute of Allergy and Infectious Diseases(n=37),and the cooperation among various institutions was close.In terms of literature authors,there were two high-yielding authors in the United States[Ralph S.Baric(n=21)and Kuochen Chou(n=17)],two Chinese authors[Yuen Kwok-yung(n=17)and Jiang Shibo(n=16)]and one Dutch author[Eric J.Snijder(n=17)].In terms of the cluster analysis of authors,the authors were closely related in reverse genetics,respiratory infection,receptor binding domain,etc.,and the 15 top-cited papers came mainly from China,the United States,Netherlands and other countries,and the literature content represented the frontiers and hot spots in different periods.The treatment hot spots focused on preventing virus adsorption,inhibiting the virus gene nucleic acid replication,transcription and translation.The main subject words were divided into three main categories,namely,CoVs epidemiology,basic research and drug development,in which basic research and drug development were strongly correlated.In the subject words breakthrough analysis,there were time-related breakthrough points in 1991,1996 and 2002,and the"diagnosis"and"sequence"were continuous hot spots.Conclusions Through the visualization analysis of knowledge graph,the development trend and hot spots of CoVs therapy research could be well observed.In this study,the degree of attention in the field of CoVs treatment showed periodic changes,related to the outbreak of new CoVs,and the country,institutions and the author were closely related.The treatment hot spots focused on preventing virus adsorption,inhibiting the virus gene nucleic acid replication,transcription and translation in order to develop new targets of drug.