老年2型糖尿病患者血清热休克蛋白60和Nesfatin-1水平与胰岛素抵抗的相关性

Correlation between serum heat shock protein 60,Nesfatin-1 levels and insulin resistance in elderly type 2 diabetes mellitus patients

目的探讨老年2型糖尿病(T2DM)患者血清热休克蛋白60(HSP60)、Nesfatin-1水平与胰岛素抵抗(IR)的相关性,旨在为临床诊疗T2DM提供依据。方法选取2018年3月至2019年3月保定市第一中心医院收治的98例老年T2DM患者作为观察组,另选取同期糖耐量正常的健康体检者40例作为对照组。比较两组调查对象和不同糖化血红蛋白(HbA1C)水平患者血清HSP60、Nesfatin-1水平和胰岛素抵抗指数(HOMA-IR),比较不同HOMA-IR患者血清HSP60和Nesfatin-1水平,分析老年T2DM患者血清HSP60、Nesfatin-1水平与HOMA-IR的相关性。用SPSS 22.0软件处理数据,计量资料的组间比较用t检验,采用Pearson进行相关性分析。结果观察组血清HSP60、Nesfatin-1水平和HOMA-IR均明显高于对照组,差异均有统计学意义(P<0.05,P<0.01)。HbA1C<9%患者血清HSP60、Nesfatin-1水平和HOMA-IR均明显低于HbA1C≥9%患者,差异均有统计学意义(P<0.01)。HOMA-IR<3患者血清HSP60和Nesfatin-1水平均明显低于HOMA-IR≥3患者,差异均有统计学意义(P<0.01)。老年T2DM患者血清HSP60和Nesfatin-1水平与HOMA-IR均呈明显的正相关(r值分别为0.345、0.369,P<0.01)。结论血清HSP60和Nesfatin-1水平在老年T2DM患者中呈现异常高表达状态,且与HOMA-IR呈明显的正相关,可为临床诊断、判断病情程度、制定治疗方案提供可靠的参考依据。

Objective To explore the relationship between serum heat shock protein 60(HSP60),Nesfatin-1 levels and insulin resistance(IR)in elderly patients with type 2 diabetes mellitus(T2 DM),and to provide basis for the clinical diagnosis and treatment of T2 DM.Methods A total of 98 elderly T2 DM patients admitted to Baoding First Central Hospital from March of 2018 to March of 2019 were enrolled as the observation group.Forty healthy subjects with normal glucose tolerance were selected as the control group.The patient serum HSP60 levels,Nesfatin-1 levels and insulin resistance index(HOMA-IR)between two groups and glycosylated hemoglobin(HbA1 C)level patients were compared;the serum HSP60 levels and Nesfatin-1 levels among patients with different HOMA-IR were compared;the correlations between HSP60 or Nesfatin-1 and HOMA-IR were analyzed.The t test was used to analyze the differences between two groups,Pearson correlation analysis was used to analyze the correlation between serum HSP60,Nesfatin-1 and HOMA-IR,the used software was SPSS 22.0.Results Serum HSP60,Nesfatin-1 levels and HOMA-IR in the observation group were significantly higher than those in the control group(P<0.05,P<0.01).Serum HSP60,Nesfatin-1 levels and HOMA-IR in HbA1 C<9%patients were significantly lower than those in HbA1 C≥9%patients(P<0.01).Serum HSP60 and Nesfatin-1 levels in HOMA-IR<3 patients were significantly lower than those in HOMA-IR≥3 patients(P<0.01).Serum HSP60 and Nesfatin-1 levels were positively correlated with HOMA-IR in elderly T2 DM patients(r values were 0.345 and0.369,P<0.01).Conclusion Serum levels of HSP60 and Nesfatin-1 are abnormally high expression in elderly T2 DM patients,and have a positive correlation with HOMA-IR.It can provide a reliable reference for clinical diagnosis,judgment of disease severity and treatment protocol.