肿瘤糖基化在肿瘤免疫逃避中的意义

Implications of Tumor Glycosylation in Tumor Immune Evasion

肿瘤细胞上的异常糖基化与肿瘤免疫调节有密切关系,但肿瘤糖基化的免疫逃逸作用大多数被疏忽。异常肿瘤糖基化改变了免疫系统对肿瘤识别,并通过凝集素诱导免疫抑制。异常O-聚糖在肿瘤免疫过程中所涉及免疫抑制作用,也被认为是一种免疫逃逸系统。此外,HIF-1α也被证明可诱导肿瘤细胞中糖基转移酶和糖转运蛋白的表达,使肿瘤的生长活性增强,导致肿瘤的侵袭力增强,被认为是独特的缺氧驱动糖编码。肿瘤糖基化有望成为肿瘤免疫治疗的新靶点。

Abnormal glycosylation on tumor cells is closely related to tumor immune regulation,however,the effects of tumor glycosylation on immune escape are mostly neglected.Abnormal tumor glycosylation alters recognition of tumors by immune system and induces immunosuppression through glycan-binding lectins.The immunosuppressive effect of abnormal O-glycan in the tumor immune process is also considered as an immune escape system.In addition,HIF-1αhas been shown to induce the expression of glycosyltransferases and sugar transporters in tumor cells,enhance the growth activity of tumors,and lead to increased tumor invasion,so it is considered as a specific hypoxia-induced sugar coding factor.Tumor glycosylation is expected to be a novel target for tumor immunotherapy.