放疗抗肿瘤免疫调节作用

Immunomodulatory Effect of Cancer Radiotherapy

放疗是一种免疫调节工具,具有免疫刺激作用,越来越多的证据表明放疗通过诱导特异性T细胞的启动、激活免疫系统、改善肿瘤微环境、增加淋巴细胞介导的细胞毒性的敏感性及调节免疫检查点的表达发挥抗肿瘤免疫反应。全文阐述了放疗调节机体的免疫特性,增加抗肿瘤免疫反应,回顾了近年来将放疗与免疫治疗特别是免疫检查点阻滞剂相结合具有协同作用的临床前试验和临床试验,以供临床参考。

Radiotherapy is widely used for cancer treatment and it also has immunomodulatory effects. Increasing evidence has revealed that radiotherapy induces the activation of specific T cells,activates the immune system,improves the tumor microenvironment,increases the sensitivity of lymphocyte-mediated cytotoxicity and regulates the expression of the immune checkpoint to exert an anti-tumor immune response. This article summarizes how radiotherapy regulates the immune function of the body and increases the anti-tumor immune response,and also reviews recent preclinical and clinical studies on the combination of radiotherapy with immunotherapy,especially immunocheck point blockers in cancer treatment.