摘要
肿瘤的多药耐药(MDR)是导致癌症复发和转移的重要因素.ATP结合盒转运蛋白(ABC转运蛋白)在人体广泛存在,并且ABC转运蛋白的过度表达是导致肿瘤细胞产生MDR的主要原因之一.利用分子影像技术对MDR肿瘤进行早期监测,有利于临床医师制定有效的治疗方案,并在一定程度上能改善肿瘤患者的预后.笔者就分子影像技术在监测MDR方面的研究进展进行简要综述.
Tumor multidrug resistance(MDR)is an important factor that leads to cancer recurrence and metastasis.ATP-binding cassette transporters are widely present in humans,and their overexpression mainly induces MDR in tumor cells.Molecular imaging for the early monitoring of MDR tumors is helpful for clinicians to formulate effective treatment plans and improve tumor prognosis to a certain extent.This study briefly reviews the research progress on molecular imaging for MDR monitoring.
作者
叶敏
夏晓天
兰晓莉
张永学
Ye Min;Xia Xiaotian;Lan Xiaoli;Zhang Yongxue(Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Key Laboratory of Molecular Imaging)
出处
《国际放射医学核医学杂志》
2020年第3期174-181,共8页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金(81771863、81630049、81801737)。
