FGF18与骨性关节炎患者血清炎症细胞因子、脂肪细胞因子及骨关节严重程度的相关性

Correlation between FGF18 and serum inflammatory cytokines,adipokines and bone and joint severity in patients with osteoarthritis

目的探究成纤维细胞生长因子18(FGF18)与骨性关节炎(OA)患者血清炎症细胞因子、脂肪细胞因子及骨关节严重程度的相关性。方法选取于本院进行诊断和治疗的120例OA患者,根据Kellgren⁃Lawrence(K⁃L)分级至少2级,并分为KL2组(n=53)、KL3组(n=39)、KL4组(n=28),并选取同期健康志愿者30例作为对照组,对比各组血清FGF18、炎症细胞因子[肿瘤坏死因子⁃α(TNF⁃α)、白细胞介素⁃1β(IL⁃1β)、IL⁃6、IL⁃17、IL⁃23]、脂肪细胞因子[瘦素(Leptin)、脂联素(APN)、内脂素(visfatin)]水平,Spearman相关性分析各指标见的相关性。结果OA患者各组FGF18水平显著低于对照组,且K⁃L分级越高,FGF18水平越低,各组比较差异具有统计学意义(P<0.05)。OA患者相比于对照组炎症细胞因子TNF⁃α、IL⁃1β、IL⁃6、IL⁃17、IL⁃23水平均显著升高,且K⁃L分级各组各指标比较差异具有统计学意义(P<0.05)。与对照组比较,OA患者Leptin、visfatin水平显著升高,APN水平显著降低,且K⁃L分级各组各指标比较差异具有统计学意义(P<0.05)。相关性分析结果显示,FGF18与K⁃L分级、TNF⁃α、IL⁃1β、IL⁃6、IL⁃17、IL⁃23、Leptin、visfatin存在显著负相关性,与APN存在显著正相关性(P<0.05)。结论随着OA患者骨关节疾病严重程度增加,FGF18水平随之降低,这可能与OA患者血清炎症细胞因子和脂肪细胞因子异常表达有关,检测相关指标对于OA患者病情评估及治疗具有重要意义。

Objective To investigate the correlation between fibroblast growth factor 18(FGF18)and serum inflammatory cytokines,adipocytokines and bone and joint severity in patients with osteoarthritis(OA).Methods 120 OA patients who were diagnosed and treated in our hospital were classified according to Kellgren⁃Lawrence(KL)at least level 2 and were divided into the KL2 group(n=53),the KL3 group(n=39),and the KL4 group(n=28),and 30 healthy volunteers in the same period were selected as the control group,and serum FGF18,inflammatory cytokines[tumor necrosis factor⁃α(TNF⁃α),interleukin⁃1β(IL⁃1β),IL⁃6,IL⁃17,IL⁃23],adipocytokines[Leptin,adiponectin(APN),visfatin]levels were measured and compared in each group.Spearman correlation analysis was used to analyze the correlation of each index.Results The serum levels of FGF18 in each group of OA patients were significantly lower than those in the control group,and the higher the KL grade,the lower the FGF18 level(P<0.05).Compared with the control group,the serum levels of inflammatory cytokines TNF⁃α,IL⁃1β,IL⁃6,IL⁃17,and IL⁃23 were significantly increased in patients with OA,and the indicators of each group in the KL classification were significantly different(P<0.05).Compared with the control group,the levels of Leptin and visfatin in OA patients were significantly increased,and the serum levels of APN were significantly reduced,and the K⁃L classification had significant differences in each index(P<0.05).Correlation analysis showed that FGF18 has a significant negative correlation with KL grade,TNF⁃α,IL⁃1β,IL⁃6,IL⁃17,IL⁃23,Leptin,and visfatin,and a significant positive correlation with APN(P<0.05).Conclusion As the severity of osteoarthritis in OA patients increases,the level of FGF18 decreases that could be related to the abnormal expression of serum inflammatory cytokines and adipocytokines in OA patients.The detection of relevant indicators in serum is of great significance for the evaluation and treatment of OA patients.