PLGF、IL⁃6与妊娠期高血压病情程度及母婴结局的相关性

Correlation between PLGF、IL⁃6 and the degree of hypertension in pregnancy of maternal and infant outcomes

目的探究胎盘生长因子(PLGF)、白介素6(IL⁃6)与妊娠期高血压病情程度及母婴结局的相关性。方法选取2017年1月至2020年2月本院收治的110例妊娠期高血压疾病患者作为研究组,包含50例妊娠期高血压、30例轻度子痫前期、30例重度子痫前期,选取同期85例正常孕妇作为对照组。比较两组PLGF、IL⁃6水平,并比较研究组不同病情程度患者PLGF、IL⁃6水平,随访统计两组母婴结局,比较研究组不同PLGF、IL⁃6水平患者的母婴结局,采用Spearman分析PLGF、IL⁃6水平与病情程度、母婴结局相关性。结果研究组PLGF水平低于对照组,IL⁃6水平高于对照组(P<0.05);研究组不同病情程度IL⁃6水平对比,重度子痫前期>轻度子痫前期>妊娠期高血压,PLGF水平对比,重度子痫前期<轻度子痫前期<妊娠期高血压(P<0.05);研究组不良母婴结局发生率(23.64%)高于对照组(3.53%,P<0.05);研究组IL⁃6高表达患者不良母婴结局发生率较低表达患者高,PLGF低表达患者不良母婴结局发生率较高表达患者高,差异无统计学意义(P>0.05);妊娠期高血压疾病患者IL⁃6水平与病情程度、母婴结局间存在正相关关系,PLGF水平与病情程度、母婴结局间存在负相关关系(P<0.05)。结论妊娠期高血压疾病患者IL⁃6水平异常升高,PLGF表达降低,与病情程度、母婴结局间存在密切关系,参与妊娠期高血压疾病的发生和病情进展,同时增加不良妊娠结局发生风险。

Objective To investigate the correlation between placental growth factor(PLGF),interleukin 6(IL⁃6)and the degree of hypertension during pregnancy and the outcomes of mothers and infants.Methods 110 patients with hypertension during pregnancy who were admitted to our hospital from January 2017 to February 2020 were selected as the study group,including 50 cases of hypertension during pregnancy,30 cases of mild preeclampsia,30 cases of severe preeclampsia,85 normal pregnant women were selected as the control group during the same period.The levels of PLGF and IL⁃6 between the two groups,and in patients with different degrees of illness in the study group were measured and compared.The maternal and infant outcomes of the two groups were followed up and compared,the mother and infant outcomes of patients with different PLGF and IL⁃6 levels in the study group were analyzed.Spearman was used to analyze the correlation of PLGF and IL⁃6 levels with the degree of illness and maternal and infant outcomes.Results PLGF levels in the study group were lower than those in the control group,and IL⁃6 levels were higher than those in the control group(P<0.05);comparison of IL⁃6 levels in the study group with different degrees of illness,severe preeclampsia>mild preeclampsia>hypertension in pregnancy,compared with PLGF levels,severe preeclampsia<mild preeclampsia<hypertension in pregnancy(P<0.05).The incidence of adverse maternal and child outcomes in the study group(23.64%)was higher than that in the control group(3.53%,P<0.05);the incidence of adverse maternal and infant outcomes in patients with high IL⁃6 expression in the study group was higher in patients with lower expressions,and the incidence of adverse maternal and infant outcomes in patients with low expression of PLGF was higher,but the difference was not statistically significant(P>0.05).There was a positive correlation between IL⁃6 levels and the degree of illness and maternal and infant outcomes in patients with hypertension during pregnancy,and a negative correlation between the level of PLGF and the degree of illness and maternal and infant outcomes(P<0.05).Conclusion The levels of IL⁃6 in patients with hypertension during pregnancy are abnormally elevated,and the expression of PLGF is reduced,which is closely related to the degree of disease and maternal and child outcomes.IL⁃6 and PLGF are involved in the occurrence and progression of hypertension during pregnancy and increases the risk of adverse pregnancy outcomes.