摘要
长链非编码RNA(LncRNA)是一类位于细胞核或胞质内长度大于200 nt的非编码RNA。LncRNA GAS5是一名近年开始受到关注的LncRNA家族成员,它的基因位于人类1号染色体长臂2区5带,全长4087 nt,由12个外显子组成。多项研究表明,LncRNA GAS5参与炎症反应,介异血管内皮细胞损伤,在动脉粥样硬化及相关疾病发生发展中起重要的作用。本文就它在动脉粥样硬化及相关疾病发生发展中的作用作一评述。
LongNon⁃Coding RNA(LncRNA)is a type of RNA that is located in the nucleus or cytoplasm and is longer than 200 nt.LncRNA GAS5 is a member of the LncRNA family that has attracted attention in recent years.The encoding gene is in the q25 regio of human chromosome 1,has a total length of 4087 nt and consists of 12 exons.Several studies have shown that LncRNA GAS5 is involved in inflammation,mediates vascular endothelial cell damage,and plays an important role in the development of atherosclerosis and related diseases.This article reviews the role of LncRNA GAS5 in the occurrence and development of atherosclerosis and atherosclerosis⁃related diseases.
作者
韦贵将
杨峻
韦叶生
WEI Guijiang;YANG Jun;WEI Yesheng(Department of Medical Laboratory,Affiliated Hospital of Guilin Medical University,Guilin,Guangxi,China,541000;Medical College of Guangxi University,Nanning,Guangxi,China,530000;Department of Medical Laboratory,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise,Guangxi,China,533000)
出处
《分子诊断与治疗杂志》
2020年第4期401-405,F0002,共6页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金项目(81560552)
广西重点研发课题(2018AB58018)
广西自然科学基金(2018GXNSFAA138120)。
