外周血CD40、CD40L表达及血清BAFF水平对ITP患者疗效的预测价值

The predictive value of peripheral blood CD40,CD40L expression and serum BAFF level on the efficacy of patients with immune thrombocytopenic purpura

目的探讨外周血CD40、CD40L表达及血清BAFF水平对ITP患者疗效的预测价值。方法选择本院接治的ITP患者80例(观察组)及同期健康体检患者100例(对照组)进行研究。两组均行外周血CD40、CD40L表达及血清BAFF水平检测,根据疗效判断结果将观察组患者分为治疗反应组及治疗无反应组。对比2组外周血CD40、CD40L表达及血清BAFF水平,并对不同疗效患者外周血CD40、CD40L表达及血清BAFF水平进行对比。结果观察组外周血CD40、CD40L表达及血清BAFF水平均明显高于对照组(P<0.05)。治疗无反应组患者患者外周血CD40、CD40L表达及血清BAFF水平均明显高于治疗反应组(P<0.05)。ITP患者外周血CD40、CD40L表达及血清BAFF水平均与疗效呈显著负相关(r<0,P<0.05)。ROC曲线分析结果显示外周血CD40、CD40L及BAFF对ITP疗效预测价值较高(均AUC>0.7,P<0.05)。结论ITP患者外周血CD40、CD40L对ITP患者疗效具有较高的预测价值。

Objective To investigate the predictive value of peripheral blood CD40,CD40L ex⁃pression and serum BAFF level in the treatment of immune thrombocytopenic purpura(ITP)patients.Meth⁃ods 80 patients with ITPadmitted to our hospital wererecruited as the observation group.100 healthy people who underwent physical examination in our hospital were selected as the control group.Peripheral blood CD40,CD40L expression and serum BAFF level were observed in both groups.The patients were divided into two groups according to the results of efficacy judgment.The expression of CD40,CD40L and serum BAFF in peripheral blood from the two groups were compared.Results The expression of CD40,CD40L and serum BAFF in the peripheral blood in the observation group were significantly higher than those in the control group(P<0.05).The expression of CD40,CD40L and serum BAFF in peripheral blood of patients with non⁃response group were significantly higher than those in response group(P<0.05).The expression of CD40,CD40L and serum BAFF in peripheral blood of patients with ITP were negatively correlated with curative ef⁃fect(r<0,P<0.05).ROC curve analysis results show that the peripheral blood CD40,CD40L and BAFF have high predictive value for ITP efficacy(all AUC>0.7,P<0.05).Conclusion The peripheral blood CD40 and CD40L in patients with ITP have a high predictive value for the efficacy of ITP patients.