宫颈癌与叶酸相关信号通路的研究进展

Research progress of folate-related signaling pathways in cervical cancer

宫颈癌是常见的妇科恶性肿瘤之一,其发病率在全世界女性生殖道恶性肿瘤中位居第1,并且是20~39岁女性因癌症死亡的第2大原因。目前已知人乳头瘤病毒(HPV)感染是导致宫颈癌发生的首要病因。但是,HPV感染率虽然高,HPV感染者最终发展为宫颈癌者却很少。诱导HPV感染发生恶性转化的机制,迄今仍未阐明。叶酸可能影响多条信号通路,促进肿瘤细胞多向分化潜能增强、上皮间质转化(EMT)和有氧糖酵解发生,在肿瘤发生、发展及化疗药物的耐药中起着至关重要的作用。笔者拟对叶酸相关信号通路在宫颈癌中的研究进展进行综述,旨在探讨宫颈癌的发病机制,提高宫颈患者生存率。

Cervical cancer is one of the most common gynecological malignancies.Among female reproductive tract malignancies in the world,its incidence ranks first,and it is the second leading cause of cancer death among women aged 20-39 years old.At present,human papilloma virus(HPV)infection is the primary cause of cervical cancer.However,although the HPV infection rate is high,few people eventually develop into cervical cancer.The mechanisms that induce malignant transformation of HPV have not been fully elucidated.Folic acid may affect multiple signaling pathways,which in turn promotes the multi-directional differentiation potential of tumor cells,epithelial-mesenchymal transition(EMT),and aerobic glycolysis.It plays a vital role in tumorigenesis,tumor progression,and resistance to chemotherapy drugs.The authors intend to review the research progress of folate-related signaling pathways in cervical cancer to explore the pathogenesis of cervical cancer and improve the survival rate of cervical cancer patients.