口腔鳞状细胞癌边界精准评价的光学成像研究进展

Advancement of Optical Imaging on Precise Assessment for Surgical Margin of Oral Squamous Cell Carcinoma

口腔鳞状细胞癌是头颈部常见的恶性肿瘤之一,其治疗以手术扩大切除病灶为主,由于肿瘤位于口腔颌面部,扩大切除会对患者外观和功能带来较大影响,可造成患者术后生存质量明显下降;而另一方面,切除不足可造成术后复发。因此,精准切除病灶对于口腔鳞状细胞癌患者的预后和术后生存质量有重要意义。本文就近年来光学成像技术中的荧光成像、靶向荧光、窄带成像、高分辨率显微内镜、拉曼光谱在口腔鳞状细胞癌边界精准评价的研究进展作一综述。

Oral squamous cell carcinoma(OSCC)is the most common malignant tumors in the head and neck.The treatment of OSCC mainly focuses on surgical enlarged resection.As the tumors are located in the oral and maxillofacial region,enlarged resection will have a great impact on the appearance and function of patients,which can cause a significant decline in the quality of life of patients after surgery.On the other hand,insufficient resection can cause recurrence after surgery.Therefore,precise excision of lesions is of great significance for the survival and quality of life of patients with OSCC.In this paper,we reviewed the recent researches using optical imaging includinguorescence imaging,targeteduorescence imaging,narrow band imaging,high-resolution microendoscopy,and raman spectroscopy on the precise assessment for surgical margin of OSCC.