肠道益生菌辅助治疗非酒精性脂肪性肝病的疗效研究

Efficacy of intestinal probiotics in the treatment of nonalcoholic fatty liver disease

目的探讨肠道益生菌辅助治疗非酒精性脂肪性肝病的疗效研究。方法将2017年7月-2019年1月在我院消化内科治疗的104例非酒精性脂肪性肝病患者随机分为两组,对照组采用常规药物治疗,在此基础上观察组使用肠道益生菌辅助治疗,比较两组患者的血生化指标变化、肠道菌群指标变化、炎性因子水平变化。结果观察组治疗后ALT、AST、HMW-APN、TC、TG、LDL-C、FPG水平低于对照组,而HDL-C水平高于对照组,有统计学意义(P<0.05);观察组治疗后双歧杆菌数、大肠杆菌数、B/E高于对照组,有统计学意义(P<0.05);观察组治疗后IL-18、IFN-γ水平低于对照组,而IL-10水平高于对照组,有统计学意义(P<0.05)。结论肠道益生菌辅助治疗非酒精性脂肪性肝病的疗效显著,能有效改善血脂代谢,调节肝功能,调整肠道菌群水平,抑制机体炎症水平,从而改善病情,抑制肝损伤。

Objective To investigate the efficacy of intestinal probiotics in the treatment of non-alcoholic fatty liver disease.Methods From January 2017 to January 2019 in our hospital of medical treatment of 104 patients with nonalcoholic fatty liver disease were randomly divided into two groups,control group using conventional drug treatment,on the basis of the observation group used in the adjuvant treatment of intestinal probiotics,comparing two groups of patients with blood biochemical index,index of intestinal flora changes and inflammatory factor levels change.Results After treatment,ALT,AST,hmw-apn,TC,TG,ldl-c and FPG levels in the observation group were significantly lower than those in the control group,while hdl-c levels were significantly higher than those in the control group(P<0.05).After treatment,the number of bifidobacteria,e.coli and B/E in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of il-18 and IFN-in the observation group were significantly lower than those in the control group,while the levels of il-10 were significantly higher than those in the control group(P<0.05).Conclusion Intestinal probiotics adjuvant treatment of non-alcoholic fatty liver disease has a significant effect,which can effectively improve blood lipid metabolism,regulate liver function,adjust the level of intestinal flora,inhibit the level of inflammation in the body,so as to improve the condition and inhibit liver injury.