基于AGREEⅡ的严重过敏反应诊疗指南质量评价

A Systematic Quality Appraisal of Anaphylaxis Diagnosis and Treatment Guidelines Using the AGREE Ⅱ Instrument

目的:循证评价现有严重过敏反应诊疗指南的质量,为临床工作者选用相关指南及我国严重过敏反应急救指南的制订提供参考。方法:系统检索PubMed、Embase、the Cochrane Library、Web of Science、SinoMed、CNKI、WanFang Data及4个指南文库。对符合纳入标准的指南采用AGREEⅡ评估工具评价指南的方法学质量。结果:纳入的8部指南在清晰性领域的平均分最高,在严谨性领域的平均分最低。European Academy of Allergy and Clinical Immunology(EAACI)指南总体质量最高。结论:建议指南制订工作组重视方法学家的参与,以提高指南严谨性。对于现有的严重过敏反应诊疗指南,一般情况优先推荐EAACI指南。

Objective:To appraise the methodological quality of available clinical guidelines involving diagnosis and treatment of anaphylaxis by evidence-based method, in order to help the health care providers to make decision and make preparations for the development of China’s anaphylaxis guideline. Methods:PubMed, Embase, the Cochrane Library, Web of Science, SinoMed, CNKI, WanFang Data and four guidelines databases had been systematically retrieved. The methodologic quality of clinical guidelines meeting the inclusion criteria was assessed with AGREE Ⅱ.Results:8 included guidelines made the highest average score in the ‘clarity of presentation’ domain,while got the lowest in the ‘rigour of development’ domain. The guideline of European Academy of Allergy and Clinical Immunology(EAACI) was evaluated as the top-quality one. Conclusion:The participation of methodologists while developing clinical guidelines should be paid attention to. Among current diagnosis and treatment guidelines for anaphylaxis, the EAACI guideline, answering basic clinical questions comprehensively, was normally recommended first.