以中医证候量表评价利培酮联合达营片治疗精神分裂症的疗效

Effect of risperidone combined with Daying tablets in the treatment of schizophrenia assessed with Chinese medical symptoms scale

目的 :以中医证候量表评价抗精神病药合并达营片治疗精神分裂症的临床疗效。方法 :采用随机双盲对照研究,对住院精神分裂症患者随机分成研究组和对照组。两组患者在单一使用利培酮的基础上,研究组加用达营片,对照组使用安慰剂,治疗12周,使用自拟中医证候量表进行疗效评估。结果 :治疗后两组阳性症状、阴性症状、中医躯体症状或体征及总分均有改善,其中,研究组在阴性症状方面的改善显著优于对照组(P<0.01)。中医证候量表评分与PANSS量表评分成正相关。结论 :利培酮联合达营片更有利于对阴性症状的治疗。

Objective:To explore the clinical efficacy of risperidone combined with Daying tablets in patients with schizophrenia assessed with Chinese medical symptoms scale.Methods:A randomized,double-blind,placebo-controlled trial was administered.Inpatients with schizophrenia were all treated with risperidone and then randomly divided into a study group and a control group.The study group was additionally treated with Daying tablet while the control group with placebo for 12 weeks.The efficacy was evaluated by PANSS and Chinese medical symptoms scale.Results:The positive and negative psychiatric symptoms,the physical symptoms and the total scores of Chinese medical symptoms scale were all improved after treatment and the improvement of the negative symptom was significantly better in the study group than the control group(P<0.01).The score of the Chinese medical symptoms scale was positively correlated with PANSS scale score.Conclusion:The combination of risperidone with Daying tablets is more conductive to the treatment of negative symptoms.