摘要
Summary of main observation and conclusion A highly eficient palladium-catalyzed direct coupling of propargylic alcohols with organoboronic acids to synthesize tri-and tetra-substituted llenes has been developed under mild reaction conditions.Many useful functional groups are tolerated in this pro-cess with high to excellent yields.Preliminary biological studies showed that several tri-and tetra-substituted allenes exhibited potent anti-diabetic activi-ties.
基金
Financial support from National Natural Science Foundation of China(Grant No.21690063 for S.Ma and Grant No.21801041 for H.Qian),and Shanghai Sailing Program(18YF1402000 for H.Qian)are greatly appreciated.We thank Mr.Junjie Fan in this group for reproducing the results of 3ag,3aj and 3ba presented in this study.
