Mechanisms of Chaperones as Active Assistant/Protector for Proteins:Insights from NMR Studies

Molecular chaperones are diverse families of proteins that play key roles in protein homeostasis.They assist the folding of client proteins or prevent them from rreversible aggregation under stress conditions.Diverse chaper-one families contribute to different aspects of protein homeostasis by inter-acting with a wide range of client proteins.Despite the vital roles of chaper-ones in cell survival,the molecular mechanisms underlying chaperone func-tions remain elusive,due to the non-specificity of chaperone-client interac-tions and the intrinsic flexibility of the clients.