摘要
Summary The article herein briefly introduces the story of the birth of click chemistry and its evolution after that.A new angle to interpret click reac-tions was proposed using the"reactivity availability-functionality"trilogy.CuAAC(Copper-catalyzed azide-alkyne cycloaddition),the most popular click reaction by far,was revisited along with the thiol-ene,metal-free AAC,SuFEx(sulfur(VI)fluoride exchange)and the lately discovered diazotransfer pro-cess.By encountering more and more near-perfect reactions,click chemistry is evolving and expanding on the fringe of the chemistry and dfferent scien-tific disciplines,destination unknown.
基金
We acknowledge the National Natural Science Foundation of China(NSFC 21672240,NSFC 25721421002)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB200203)
the Key 258 Research Program of Frontier Sciences(CAS,Grant No.QYZDB-SSWSLH-028)
Shanghai Sciences and 259 Technology Committee(18JC1415500,18401933502)for their financial support.
